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COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study
Sheryl Ann Abdukahil, Ryuzo Abe, Laurent Abel, Lara Absil, Andrew Acker, Shingo Adachi, Elisabeth Adam, Diana Adrião, Kate Ainscough, Ali Ait Hssain, Younes Ait Tamlihat, Takako Akimoto, Tala Al-dabbous, Abdulrahman Al‐Fares, Eman Al Qasim, Razi Alalqam, Beatrice Alex, Kévin Alexandre, Huda Alfoudri, Kazali Enagnon Alidjnou, Jeffrey Aliudin, Clotilde Allavena, Nathalie Allou, João Alves, Rita Vieira Alves, Maria Esméria Corezola do Amaral, Heidi Ammerlaan, Phoebe Ampaw, Roberto Andini, Claire Andréjak, Andrea Angheben, François Angoulvant, Séverine Ansart, Massimo Antonelli, Carlos Alexandre Antunes de Brito, Yaseen M. Arabi, Irene Aragão, Antonio Arcadipane, Lukas Arenz, Jean‐Benoît Arlet, Christel Arnold-Day, Lovkesh Arora, Élise Artaud-Macari, Ángel Asensio, Jean‐Baptiste Assié, Anika Atique, Johann Auchabie, Hugues Aumaître, Laurène Azemar, Cécile Azoulay, Benjamin Bach, Delphine Bachelet, J. Kenneth Baillie, Erica Bak, Agamemnon Bakakos, Firouzé Bani‐Sadr, Renata Barbalho, William Barclay, Michaela Barnikel, Audrey Barrelet, Cleide Barrigoto, Romain Basmaci, Diego Fernando Bautista Rincón, Alexandra Bedossa, Sylvie Behilill, Aleksandr Beljantsev, David Bellemare, Anna Beltrame, Marine Beluze, Nicolas Benech, Dehbia Benkerrou, Suzanne Bennett, Luís Bento, Jan‐Erik Berdal, Delphine Bergeaud, Lorenzo Bertolino, Simon Bessis, Sybille Bevilcaqua, Krishna Bhavsar, Felwa Bin Humaid, François Bissuel, Patrick Biston, Laurent Bitker, Pablo Blanco-Schweizer, Mathieu Blot, Filomena Boccia, Debby Bogaert, François Bompart, Gareth Booth, Diogo Borges, Raphaël Borie, Jeannet C. Bos, Hans Martin Bosse, Élisabeth Botelho-Nevers, Lila Bouadma, Olivier Bouchaud, Sabelline Bouchez, Dounia Bouhmani, Damien Bouhour, Kévin Bouiller, Laurence Bouillet, Camille Bouisse, Anne‐Sophie Boureau, Maude Bouscambert, Jason Bouziotis, Bianca Boxma, Marielle Boyer-Besseyre, Maria Boylan, Cynthia Braga, Timo Brandenburger, Luca Brazzi, Dorothy Breen, Patrick J. Breen, Kathy Brickell, Nicolas Brozzi, Nina Buchtele, Christian Buesaquillo, Polina Bugaeva, Marielle Buisson, Erlina Burhan, Ingrid G. Bustos, Denis Butnaru, Sheila Cárcel, André Cabie, Susana Cabral, Eder Cáceres, Mia Callahan, Kate Calligy, Jose Andres Calvache, João Camões, Valentine Campana, Paul Campbell, Cecilia Canepa, Mireia Cantero, Pauline Caraux-Paz, Filipa Cardoso, Filipe S. Cardoso, Sofia Cardoso, Simone Carelli, Nicolas Carlier, Gayle Carney, Chloe Carpenter, Marie-Christine Carret, François Martin Carrier, Gail Carson, Maire-Laure Casanova, Mariana Cascão, José Casimiro, Bailey Cassandra, Silvia Castañeda, Nidyanara Castanheira, Guylaine Castor-Alexandre, Henry Castrillón, Ivo Castro, Ana Catarino, François-Xavier Catherine, Roberta Figueiredo Cavalin, Giulio Giovanni Cavalli, Alexandros Cavayas, Adrián Ceccato, Minerva Cervantes-Gonzalez, Anissa Chair, Catherine Chakveatze, Adrienne K Chan, Meera Chand, Julie Chas, Anjellica Chen, Yih‐Sharng Chen, Matthew Pellan Cheng, Antoine Chéret, Thibault Chiarabini, Julián Chica, Catherine Chirouze, Davide Chiumello, Hwa Jin Cho, Sung‐Min Cho, Bernard Cholley, José Pedro Cidade, José Miguel Cisneros, Barbara Wanjiru Citarella, Anna Ciullo, Jennifer Clarke, Sara Clohisey, Cassidy Codan, Caitriona Cody, Alexandra Coelho, Gwenhaël Colin, Michael Collins, Sebastiano Maria Colombo, Pamela Combs, J. P. Connelly, Marie Connor, Anne Conrad, Sofía Contreras, G Cooke, Mary Copland, Hugues Cordel, Amanda Corley, Sarah Cormican, Sabine Cornelis, Arianne Joy Corpuz, Grégory Corvaisier, Camille Couffignal, Sandrine Couffin-Cadièrgues, Roxane Courtois, Charles Crepy D’Orleans, Sabine Croonen, Gloria Crowl, Jonathan Crump, Claudina Cruz, Marc Csete, Alberto Cucino, Caroline Cullen, Matthew J. Cummings, Gerard F. Curley, Elodie Curlier, Paula Custódio, Frédérick D’Aragon, Ana da Silva Filipe, Charlène Da Silveira, Éric D’Ortenzio, Al-Awwab Dabaliz, Andrew Dagens, Heidi J. Dalton, Jo Ann Dalton, Nick Daneman, Emmanuelle A. Dankwa, Jorge Dantas, Nathalie De Castro, Diego de Mendoza, Rafael Freitas de Oliveira França, Rosanna Carmela De Rosa, Thushan I. de Silva, Peter de Vries, David A. Dean, Marie‐Pierre Debray, William Dechert, Lauren Deconninck, Romain Decours, Isabelle Delacroix, K. Delavigne, Ionna Deligiannis, Andrea Dell’Amore, Pierre Delobel, Élisa Demonchy, Emmanuelle Denis, Dominique Deplanque, Pieter Depuydt, Mehul J. Desai, Diane Descamps, Mathilde Desvallée, Santi Rahayu Dewayanti, Alpha Diallo, Sylvain Diamantis, André Ivan Bradley dos Santos Dias, Juan Jose Diaz Diaz, R. F. Díaz, Kévin Didier, Jean‐Luc Diehl, Jérôme Dimet, Vincent Dinot, Alphonsine Diouf, Yael Dishon, Félix Djossou, Annemarie B Docherty, Andy Dong, Christl A. Donnelly, Maria Donnelly, Chloe Donohue, Céline Dorival, James Joshua Douglas, Renée Douma, Nathalie Dournon, Triona Downer, Mark Downing, Tom Drake, Vincent Dubée, François Dubos, Alexandra Ducancelle, Susanne Dudman, Jake Dunning, Emanuele Durante‐Mangoni, Silvia Duranti, Lucian A. Durham, Bertrand Dussol, Xavier Duval, Anne Margarita Dyrhol-Riise, Carla Eira, José Ernesto Vidal, Mohammed El Sanharawi, Subbarao Elapavaluru, Brigitte Elharrar, Natalie Elkheir, Jacobien Ellerbroek, Rachael Ellis, Philippine Eloy, Tarek M. Elshazly, Isabelle Enderle, Ilka Engelmann, Vincent Enouf, Olivier Épaulard, Mariano Esperatti, Hélène Espérou, Marina Esposito‐Farèse, Jo�ão Estêv�ão, Manuel Etienne, Nadia Ettalhaoui, Anna Greti Everding, Mirjam Evers, Isabelle Fabre, Amna Faheem, Arabella Fahy, Cameron J. Fairfield, P. Olívio Gosuen De Faria, Nataly Farshait, Arie Zainul Fatoni, Karine Faure, Mohamed Fayed, Niamh Feely, Jorge Fernandes, Marília Andreia Fernandes, S. Fernandes, Joana Ferrão, Eglantine Ferrand Devouge, Mário Ferraz, Benigno Ferreira, Ricard Ferrer, Claudia Figueiredo-Mello, C. Flateau, Tom Fletcher, Claire Foley, Victor Fomin, Cláudio Duarte Fonseca, Tatiana Fonseca, Patricia Fontela, Simon Forsyth, Giuseppe Foti, Erwan Fourn, Rob Fowler, Diego Franch-Llasat, Christophe Fraser, John F. Fraser, Marcela Vieira Freire, Ana Freitas Ribeiro, Caren Friedrich, Stéphane Fry, Nora Fuentes, Masahiro Fukuda, Joan Gómez‐Junyent, Valérie Gaborieau, Benoît Gachet, Rostane Gaci, Massimo Gagliardi, Jean-Charles Gagnard, Amandine Gagneux‐Brunon, Sérgio Gaião, Phil Gallagher, Elena Gallego Curto, Carrol Gamble, A.R. Garan, Esteban García-Gallo, Rebekha Garcia, Denis Garot, Valérie Garrait, Nathalie Gault, Aisling Gavin, Alexandre Gaymard, Johannes Gebauer, Louis Gerbaud Morlaes, Nuno Germano, Jade Ghosn, Marco Giani, Carlo Giaquinto, Jess Gibson, Tristan Gigante, Morgane Gilg, Guillermo Giordano, Michelle Girvan, Valérie Gissot, Gezy Giwangkancana, Daniel Glikman, Petr Glybochko, Eric Gnall, Geraldine Goco, François Goehringer, Siri Goepel, Jean‐Christophe Goffard, Jonathan L. Golob, Isabelle Gorenne, Cécile Goujard, Tiphaine Goulenok, Margarite Grable, E. Wilson Grandin, Pascal Granier, Giacomo Grasselli, Christopher Green, William Greenhalf, S. Greffe, Domenico Luca Grieco, Matthew Griffee, Fiona Griffiths, Ioana Grigoraș, Albert Groenendijk, Anja Große Lordemann, Heidi Gruner, Yusing Gu, Jérémie Guedj, Dewi Guellec, Anne‐Marie Guerguerian, Daniela Guerreiro, Romain Guéry, Anne Guillaumot, Laurent Guilleminault, Thomas Guimard, Daniel A. Haber, Sheeba Hakak, Matthew Hall, Sophie Halpin, Ansley Hamer, Rébecca Hamidfar, Terese Hammond, Hayley Hardwick, Kristen Harley, Ewen M. Harrison, Leanne Hays, Jan Heerman, Lars Heggelund, Ross Hendry, Martina Hennessy, Aquiles R. Henríquez-Trujillo, Maxime Hentzien, Jaime Hernández-Montfort, Astarini Hidayah, Dawn Higgins, Eibhilin Higgins, Samuel Hinton, Hiroaki Hiraiwa, Julian A. Hiscox, Antonia Ho, Alexandre Hoctin, Isabelle Hoffmann, Oscar Hoiting, Rebecca Holt, Jan Cato Holter, Peter Horby, Juan Pablo Horcajada, Koji Hoshino, Kota Hoshino, Catherine L. Hough, Jimmy Ming-Yang Hsu, Jean‐Sébastien Hulot, Samreen Ijaz, Hajnal-Gabriela Illes, Hugo Inácio, Carmen Infante Dominguez, Εlias Iosifidis, Lacey Irvine, Sarah Isgett, Tiago Isidoro, Margaux Isnard, Junji Itai, Daniel Ivulich, Salma Jaafoura, Julien Jabot, Clare Jackson, Nina Jamieson, Stéphane Jauréguiberry, Jeffrey Javidfar, Zabbe Jean-Benoît, Florence Jego, Synne Jenum, Ruth Jimbo-Sotomayor, Ruth Noemí Jorge GarcÍa, Cédric Joseph, Mark Joseph, Philippe Jouvet, Hanna Jung, Ouifiya Kafif, Florentia Kaguelidou, Sabina Kali, Smaragdi Kalomoiri, Darshana Hewa Kandamby, Christopher Kandel, Ravi Kant, Christiana Kartsonaki, Daisuke Kasugai, Kevin Katz, Simreen Kaur Johal, Seán Keating, Andrea Kelly, Sadie Kelly, Lisa Kennedy, Kalynn Kennon, Younes Kerroumi, Evelyne Kestelyn, Imrana Khalid, Antoine Khalil, Coralie Khan, Irfan Ullah Khan, Michelle E. Kho, Saye Khoo, Yuri Kida, Peter Kiiza, Anders Benjamin Kildal, Antoine Kimmoun, Detlef Kindgen‐Milles, Nobuya Kitamura, Paul Klenerman, Gry Kloumann Bekken, Stephen R Knight, Robin Kobbe, Malte Kohns Vasconcelos, Volkan Korten, Caroline Kosgei, Karolina Krawczyk, Pavan Kumar Vecham, Deepali Kumar, Ethan Kurtzman, Demetrios J. Kutsogiannis, Konstantinos G. Kyriakoulis, Erwan L’Her, Marie Lachâtre, Marie Lacoste, John G. Laffey, Marie Lagrange, Fabrice Laine, Marc Lambert, François Lamontagne, Marie Langelot-Richard, Eka Yudha Lantang, Marina Lanza, Cédric Laouenan, Samira Laribi, Delphine Larivière, Odile Launay, Yoan Lavie‐Badie, Andrew Law, Clément Le Bihan, Cyril Le Bris, Eve Le Coustumier, Georges Le Falher, Sylvie Le Gac, Quentin Le Hingrat, Marion Le Maréchal, Soizic Le Mestre, Vincent Le Moing, Hervé Le Nagard, Paul Le Turnier, Rafael León, Minh Le, Marta Santos, Ema Leal, James Lee, Su Hwan Lee, Todd A. Lee, Gary Leeming, Bénédicte Lefebvre, Laurent Lefèbvre, Benjamin Lefèvre, François Lellouche, Adrien Lemaignen, Véronique Lemee, Gretchen Lemmink, Michela Leone, Quentin Lepiller, François-Xavier Lescure, O. Lesens, Mathieu Lesouhaitier, Claire Lévy‐Marchal, Bruno Lévy, Yves Lévy, Gianluigi Li Bassi, Janet Liang, Wei Shen Lim, Bruno Lina, Andreas Lind, Guillaume Lingas, Sylvie Lion-Daolio, Keibun Liu, Antonio Loforte, Navy Lolong, Diogo Lopes, Dalia López‐Colón, Paul Loubet, Jean Christophe Lucet, Carlos M. Luna, Olguța Lungu, Liem Luong, Dominique Luton, Fredrik Müller, Karl Erik Müller, Olavi Maasikas, Sarah MacDonald, Moïse Machado, G. Macheda, Juan Macías Sánchez, Jai Madhok, Rafaël Mahieu, Sophie Mahy, Lars S. Maier, Mylène Maillet, Thomas Maitre, Maximilian Malfertheiner, Nadia Shamshad Malik, Fernando Maltêz, Denis Malvy, Marina Mambert, Victoria Manda, Jose M. Mandei, Edmund Manning, Aldric Manuel, Ceila Maria Sant, Ana Malaque, Flávio Marino, Carolline Araujo, Charbel Maroun‐Eid, Ana Marques, Catherine Marquis, Brian Marsh, Laura Marsh, John Marshall, Celina Maria Turchi Martelli, Guillaume Martin‐Blondel, Ignacio Martín‐Loeches, Alejandro Martín‐Quirós, Dori-Ann Martin, Emily Martin, M. Martinot, Caroline Martins Rego, Ana Martins, João Martins, Gennaro Martucci, Eva Miranda Marwali, Juan Fernado Masa Jimenez, David M. Maslove, Sabina Mason, Moshe Matan, Daniel Mathieu, Mathieu Mattèi, Romans Matulevics, Laurence Maulin, Natalie Mc Evoy, Aine McCarthy, Colin McCloskey, Rachael McConnochie, Sherry McDermott, Sarah McDonald, Samuel McElwee, Natalie McEvoy, Allison McGeer, Niki McGuinness, Kenneth A McLean, Bairbre McNicholas, Edel Meaney, Cécile Mear-Passard, Maggie Mechlin, Ferruccio Mele, Kusum Menon, France Mentré, Alexander J. Mentzer, Noémie Mercier, Antoine Merckx, Blake Mergler, Laura Merson, António Pedro Mesquita, Agnès Meybeck, Alison Meynert, Vanina Meyssonnier, Amina Meziane, Medhi Mezidi, Céline Michelanglei, Vladislav Mihnovitš, Hugo Miranda Maldonado, Mary C. Mone, Asma Moin, David Molina, Elena Molinos, Agostinho Monteiro, Claudia Montes, Giorgia Montrucchio, Sarah Moore, Shona C. Moore, Lina Morales-Cely, Lucía Moro, Ana Motos, Hugo Mouquet, Clara Mouton Perrot, Julien Moyet, Jimmy Mullaert, Daniel Munblit, Derek Murphy, Marlène Murris, Dimitra Melia Myrodia, Yohan N’Guyen, Nadège Néant, Holger Neb, Nikita Nekliudov, Raul Neto, Emily Neumann, Bernardo Neves, Pauline Yeung Ng, Wing Yiu Ng, Orna Ní Choileáin, Alistair Nichol, Stephanie Nonas, Marion Noret, Lisa Norman, Alessandra Notari, Mahdad Noursadeghi, Karolina Nowicka, Saad Nseir, Jose I. Nunez, Elsa Nyamankolly, Max R. O’Donnell, Katie O’Hearn, Conar O’Neil, Giovanna Occhipinti, Tawnya Ogston, Takayuki Ogura, Tak-Hyuk Oh, Shinichiro Ohshimo, Budha Charan Singh Oinam, Ana Pinho Oliveira, J.P. Oliveira, Piero Olliaro, David S. Y. Ong, Wilna Oosthuyzen, Peter J. M. Openshaw, Claudia Milena Orozco‐Chamorro, Andrés Orquera, Javier Osatnik, Nadia Ouamara, Rachida Ouissa, Clark G. Owyang, E. Oziol, Diana Póvoas, Maïder Pagadoy, Justine Pages, Mario Palacios, Massimo Palmarini, Giovanna Panarello, Prasan Kumar Panda, Mauro Panigada, Nathalie Pansu, Aurélie Papadopoulos, Briseida Parra, Jérémie Pasquier, Fabian Patauner, Luís Patrão, Christelle Paul, Mical Paul, Jorge Paulos, William A. Paxton, Jean‐François Payen, India Pearse, Giles J. Peek, Florent Peelman, Nathan Peiffer‐Smadja, Vincent Peigne, Mare Pejkovska, Ithan D. Peltan, Rui Pereira, Daniel Pérez, Thomas Perpoint, Antonio Artigas, Lenka Petroušová, Ventzislava Petrov-Sanchez, Gilles Peytavin, Scott Pharand, Michaël Piagnerelli, Walter Picard, Olivier Picone, Marie Piel-Julian, Carola Pierobon, Carlos Pimentel, Lionel Piroth, Riinu Pius, Simone Piva, Laurent Plantier, Daniel Plotkin, Julien Poissy, Maria Pokorska‐Śpiewak, Sergio Poli, Georgios Pollakis, Jolanta Popielska, Douwe F. Postma, Pedro Póvoa, Jeff Powis, Sofia Prapa, Christian Prebensen, Jean‐Charles Preiser, Vincent Prestre, Nicholas Price, Anton Prinssen, Mark G. Pritchard, Lúcia Proença, Oriane Puéchal, Gregory Purcell, Luisa Quesada, Else Quist‐Paulsen, Mohammed Quraishi, Indrek Rätsep, Bernhard Rössler, Christian Rabaud, Marie Rafiq, Gabrielle Ragazzo, Fernando Rainieri, Nagarajan Ramakrishnan, Kollengode Ramanathan, Blandine Rammaert, C. Rapp, Menaldi Rasmin, Cornelius Rau, Stanislas Rebaudet, Sarah Redl, Brenda Reeve, Liadain Reid, Renato Barbosa Reis, Jonathan Remppis, Martine Rémy, Hanna Renk, Liliana Resende, Anne-Sophie Resseguier, Matthieu Revest, Oleksa Rewa, Luis Felipe Reyes, David Richardson, Denise Richardson, Laurent Richier, Jordi Riera, Ana Lúcia Rios, Asgar Rishu, P Rispal, Karine Risso, María Angélica Rivera Núñez, Nicholas Rizer, André Roberto, Stephanie Roberts, David Robertson, Olivier Robineau, Ferran Roche‐Campo, Paola Rodari, Simão Rodeia, Julia Rodriguez Abreu, Emmanuel Roilides, Amanda Rojek, Juliette Romaru, Roberto Roncon‐Albuquerque, Mélanie Roriz, Manuel Rosa‐Calatrava, Michael Rose, Dorothea Rosenberger, Andrea Rossanese, Bénédicte Rossignol, Patrick Rossignol, Carine Roy, Benoît Rozé, Clark D. Russell, Steffi Ryckaert, Aleksander Rygh Holten, Xavier Sánchez, Isabela Saba, Musharaf Sadat, Nadia Saïdani, Leonardo Salazar, Gabriele Sales, Stéphane Sallaberry, Hélène Salvator, Ángel Sánchez-Miralles, Olivier Sanchez, Vanessa Sancho‐Shimizu, Gyan Sandhu, Oana Săndulescu, Marlene Santos, Shirley Sarfo-Mensah, Benjamine Sarton, Egle Saviciute, Parthena Savvidou, Joshua Scarsbrook, Tjard Schermer, Arnaud Scherpereel, Marion Schneider, Stephan Schroll, Michael Schwameis, James Scott-Brown, J. T. Scott, Nicholas Sédillot, Tamara Seitz, Caroline Semaille, Malcolm G. Semple, Eric Senneville, Filipa Sequeira, Tânia Sequeira, Ellen Shadowitz, Mohammad Shamsah, Pratima Sharma, Catherine A. Shaw, Victoria Shaw, Nisreen Shiban, Nobuaki Shime, Hiroaki Shimizu, Keiki Shimizu, Sally Shrapnel, Hoi‐Ping Shum, Nassima Si Mohammed, Louise Sigfrid, Catarina Silva, Maria João Silva, Wai Ching Sin, Vegard Skogen, Sue Smith, Benjamin Smood, Michelle Smyth, Morgane Snacken, Dominic So, Monserrat Solis, Joshua Solomon, Tom Solomon, Emily C. Somers, Agnès Sommet, Myung Jin Song, Rima Song, Tae Jin Song, Michael Sonntagbauer, Edouard Soum, Maria Sousa Uva, Marta Sousa, Vicente Cés de Souza-Dantas, Alexandra Sperry, Shiranee Sriskandan, Thomas Staudinger, Stephanie-Susanne Stecher, Ymkje Stienstra, Birgitte Stiksrud, Adrian Streinu‐Cercel, Anca Streinu‐Cercel, Samantha Strudwick, Ami Stuart, David I. Stuart, Asfia Sultana, Charlotte Summers, Magdalena Surovcová Andrey A. Svistunov, Konstantinos Syrigos, Jaques Sztajnbok, Konstanty Szułdrzyński, François Téoulé, Shirin Tabrizi, Lysa Tagherset, Ewa Talarek, Sara Taleb, Jelmer Talsma, Hiroyuki Tanaka, Taku Tanaka, Hayato Taniguchi, Coralie Tardivon, Pierre Tattevin, M Azhari Taufik, Richard S. Tedder, João Teixeira, Marie-Capucine Tellier, Pleun Terpstra, Olivier Terrier, Nicolas Terzi, Hubert Tessier-Grenier, Vincent Thibault, Simon-Djamel Thiberville, Benoît Thill, A. A. Roger Thompson, Shaun Thompson, David Thomson, Emma C. Thomson, Duong Bich Thuy, Ryan S. Thwaites, Peter Timashev, Jean-François Timsit, Bharath Kumar Tirupakuzhi Vijayaraghavan, Maria Toki, Kristian Tonby, Rosario María Torres Santos-Olmo, Antoni Torres, Margarida Torres, Théo Trioux, Huynh Trung Trieu, Cécile Tromeur, Ioannis P. Trontzas, Jonathan P. Troost, Tiffany Trouillon, Christelle Tual, Sarah Tubiana, Helen Tuite, Lance Turtle, Paweł Twardowski, Makoto Uchiyama, Roman Ullrich, Alberto Uribe, Asad Usman, Luís Val-Flores, Stijn Van de Velde, Marcel van den Berge, M. van der Feltz, Nicky Van Der Vekens, Peter Van der Voort, Sylvie van der Werf, Marlice van Dyk, Laura van Gulik, Jarne Van Hattem, Steven Van Lelyveld, Carolien van Netten, Noémie Vanel, Henk Vanoverschelde, Charline Vauchy, Aurélie Veislinger, Jorge Velazco, Sara Ventura, Annelies Verbon, César Vieira, Joy Ann Villanueva, Judit Villar, Pierre-Marc Villeneuve, Andrea Villoldo, Nguyễn Văn Vĩnh Châu, Benoît Visseaux, Hannah Visser, Aapeli Vuorinen, Fanny Vuotto, Chih‐Hsien Wang, Jia Wei, Katharina Weil, Sanne Wesselius, Murray Wham, Bryan Whelan, Nicole White, Aurélie Wiedemann, Keith Wille, Evert‐Jan Wils, Ioannis Xynogalas, Jacky Y. Suen, Sophie Yacoub, Masaki Yamazaki, Yazdan Yazdanpanah, Cécile Yelnik, Stephanie T. Yerkovich, Toshiki Yokoyama, Hodane Yonis, Paul J. Young, Saptadi Yuliarto, Marion Zabbe, Kai Zacharowski, Maram Zahran, Maria Zambon, Alberto Zanella, Konrad Zawadka, Hiba Zayyad, Alexander Zoufaly
Bibliographic record
VenueInfection · 2021
Typearticle
Languageen
FieldMedicine
TopicCOVID-19 Clinical Research Studies
Canadian institutionsnot available
FundersMedical Research CouncilNational Institutes of HealthNational Heart, Lung, and Blood InstituteNational Institute for Health Research Health Protection Research UnitDepartment for International DevelopmentPublic Health EnglandUniversity of OxfordNational Center for Advancing Translational SciencesWellcome TrustAgence Nationale de la RechercheCanadian Institutes of Health ResearchImperial College LondonNational Institute of General Medical SciencesNational Institute for Health and Care ResearchHealth Research BoardBill and Melinda Gates Foundation
KeywordsMedicineVomitingObservational studyNauseaPediatricsProspective cohort studyAbdominal painCohort studyLogistic regressionCohortInternal medicine
Abstract
BACKGROUND: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. METHODS: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. RESULTS: 'Typical' symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. INTERPRETATION: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.007
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score0.025
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.007 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.082
GPT teacher head0.419
Teacher spread0.337 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations80
Published2021
Admission routes1
Has abstractyes