A global metagenomic map of urban microbiomes and antimicrobial resistance
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A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
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- Teacher spread
- 0.217 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
We present a global atlas of 4,728 metagenomic samples from mass-transit systems in 60 cities over 3 years, representing the first systematic, worldwide catalog of the urban microbial ecosystem. This atlas provides an annotated, geospatial profile of microbial strains, functional characteristics, antimicrobial resistance (AMR) markers, and genetic elements, including 10,928 viruses, 1,302 bacteria, 2 archaea, and 838,532 CRISPR arrays not found in reference databases. We identified 4,246 known species of urban microorganisms and a consistent set of 31 species found in 97% of samples that were distinct from human commensal organisms. Profiles of AMR genes varied widely in type and density across cities. Cities showed distinct microbial taxonomic signatures that were driven by climate and geographic differences. These results constitute a high-resolution global metagenomic atlas that enables discovery of organisms and genes, highlights potential public health and forensic applications, and provides a culture-independent view of AMR burden in cities.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- Cell
- Topic
- Gut microbiota and health
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- Clinical and Translational Science Center, Weill Cornell Medical CollegeNational Institute of Biomedical Imaging and BioengineeringNational Institute of Allergy and Infectious DiseasesNational Institute on Drug AbuseNational Center for Advancing Translational SciencesMedical Research CouncilWeill Cornell Medical CollegeHunter CollegeOffice of ScienceMinistry of Education and Science of UkraineYork UniversityMinistry of Education, IndiaJapan Society for the Promotion of ScienceJoint Genome InstituteKeio UniversityConselho Nacional de Desenvolvimento Científico e TecnológicoNational Cheng Kung UniversityMinisterio de Economía y CompetitividadGeneralitat de CatalunyaNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungWorldQuant FoundationNational Energy Research Scientific Computing CenterCity University of New YorkVallee FoundationAlfred P. Sloan FoundationNational Science FoundationBill and Melinda Gates FoundationEast China Normal UniversityNational Aeronautics and Space AdministrationNational Institute of General Medical SciencesCentres de Recerca de CatalunyaU.S. Department of EnergyPershing Square Sohn Cancer Research Alliance
- Keywords
- MetagenomicsBiologyGeospatial analysisMicrobiomeAntibiotic resistanceMicrobial geneticsComputational biologyEcologyGeneticsGeneBacteriaCartographyGeography
- Has abstract in OpenAlex
- yes