← Back to cohort
Pembrolizumab alone or combined with chemotherapy versus chemotherapy as first-line therapy for advanced urothelial carcinoma (KEYNOTE-361): a randomised, open-label, phase 3 trial
Thomas Powles, Tibor Csőszi, Mustafa Özgüroğlu, Nobuaki Matsubara, Lajos Géczi, Susanna Cheng, Yves Fradet, Stéphane Oudard, Christof Vulsteke, Rafael Morales‐Barrera, Aude Fléchon, Şeyda Gündüz, Yohann Loriot, Alejo Rodríguez‐Vida, Ronac Mamtani, Evan Y. Yu, Kijoeng Nam, Kentaro Imai, Blanca Homet Moreno, Ajjai Alva, D. Cascallar, Mirta Varela, Mauricio Fernández Lazzaro, Diego Kaen, Gabriela Gatica, David Hugo Flores, Agustín Falco, Matias Molina, F. Van Aelst, Brieuc Sautois, Jean‐Pascal Machiels, Denis Schallier, Leandro Brust, Liane Rapatoni, Sérgio Jobim Azevedo, GISELE LOPES MARINHO, João Paulo Holanda Soares, Carlos Dzik, Jamile Almeida Silva, André P. Fay, Joel Gingerich, Cristiano Ferrario, Kylea Potvin, Marie Vanhuyse, Mahmoud Abdelsalam, Christian Caglevic, Felipe Reyes, José Luis Leal, Francisco Francisco, Carolina Ibáñez, Florence Joly, Brigitte Laguerre, Sylvain Ladoire, Delphine Topart, Olivier Huillard, Marine Gross‐Goupil, Stéphane Culine, Gwénaëlle Gravis, Peter Reichardt, Margitta Retz, Jan Herden, David G. Pfister, Carsten Ohlman, Michael Stöeckle, Manfred P. Wirth, Anja Lorch, Peter J. Goebell, Martin Boegemann, Axel S. Merseburger, Georgios Gakis, Jens Bedke, Andreas Neisius, Christian A. Thomas, Thomas Hoefner, András Telekes, Judit Kósa, János Révész, Gyorgy Bodoky, András Csejtei, Ágnes Ruzsa, Zsuzsanna Kolonics, József Erfán, Ray McDermott, Richard Bambury, Avishay Sella, Stephen Jay Frank, Daniel Kejzman, Olesya Goldman, Eli Rosenbaum, Avivit Peer, Raanan Berger, Keren Rouvinov, David Sarid, Satoshi Fukasawa, Gaku Arai, Akito Yamaguchi, Akira Yokomizo, Tatsuya Takayama, Hidefumi Kinoshita, Eiji Kikuchi, Ryuichi Mizuno, Yasuhisa Fujii, Naoto Sassa, Yoshihisa Matsukawa, Kiyohide Fujimoto, Toshiki Tanikawa, Yoshihiko Tomita, Kazuo Nishimura, Masao Tsujihata, Masafumi Oyama, Naoya Masumori, Hiro‐omi Kanayama, Toshimi Takano, Yuji Miura, Jun Miyazaki, Akira Joraku, Tomokazu Kimura, Yoshiaki Yamamoto, Kazuki Kobayashi, Ronald de Wit, Maureen J.B. Aarts, Winald R. Gerritsen, Maartje Los, Laurens V. Beerepoot, А. А. Измайлов, Sergey Gorelov, B. Yа. Alekseev, Andrey Semenov, Vladimir Kostorov, С. М. Алексеев, A. V. Zyryаnov, Vasiliy Nikolaevich Oschepkov, Vladimir A. Shidin, Vladimir Vladimirov, Rustem Gafanov, Petr Karlov, David Anderson, Lucinda Shepherd, Graham Cohen, Bernardo Louis Rapoport, Paul Ruff, Nari Lee, Woo Kyun Bae, Hyo Jin Lee, Urbano Anido Herranz, Enrique Grande, Teresa Alonso Gordoa, D. Castellano Gauna, José Ángel Arranz, José Muñoz-Langa, Regina Gironés Sarrió, Á. Montesa Pino, María José Juan-Fita, Yu‐Li Su, Yung‐Chang Lin, Wen-Pin Su, Ying‐Chun Shen, Yen‐Hwa Chang, Virote Sriuranpong, Phichai Chansriwong, Vichien Srimuninnimit, Pongwut Danchaivijitr, Hüseyin Abalı, Sinan Yavuz, Özgür Özyılkan, Mehmet Alı Nahıt Şendur, Meltem Ekenel, Çağatay Arslan, Mustafa Özdoğan, Alison Birtle, Robert Huddart, Maria De Santis, Anjali Zarkar, Linda Evans, Syed A. Hussain, Christopher DiSimone, Antonio F Muina, Peter N. Schlegel, Haresh Jhangiani, Michael R. Harrison, Dennis Slater, David J. Wright, Ivor Percent, Jianqing Lin, Clara Hwang, Sumati Gupta, Madhuri Bajaj, Robert Galamaga, John Eklund, James A. Wallace, Mikhail Shtivelband, Jason Suh, Nafisa Burhani, Matthew Eadens, Krishna S. Gunturu, Earle F. Burgess, John Wong, Arvind Chaudhry, Peter J. Van Veldhuizen, Stephanie L. Graff, Ian D. Schnadig, Benedito A. Carneiro, Maha Hussain, Alicia K. Morgans, John T Fitzharris, Ira A. Oliff, Jacqueline Vuky, Ralph J. Hauke, Ari David Baron, Monika Joshi, Britt Haley Bolemon, Peter Jiang, Anthony Mega, Maurice Markus, Nicklas Pfanzelter, William Lawler, Patrick Cobb, Jay Courtright, Sharad Jain, Gurjyot K. Doshi, Vijay Gunuganti, Oliver A. Sartor, Scott Cole, Hani Babiker, Edward Uchio, Alexandra Drakaki, Heather D. Mannuel, Elizabeth A. Guancial, Chunkit Fung, Anthony Charles, Robert J. Amato, Yull Arriaga, I. Alex Bowman, Steven Ades, Robert Dreicer, David I. Quinn, Mark T. Fleming
Bibliographic record
VenueThe Lancet Oncology · 2021
Typearticle
Languageen
FieldMedicine
TopicBladder and Urothelial Cancer Treatments
Canadian institutionsUniversité LavalSunnybrook Health Science Centre
FundersJanssen PharmaceuticalsMerck Sharp and DohmeBritish Microcirculation SocietyNovartisSanofiMerckGlaxoSmithKlineEli Lilly and CompanyAstraZenecaBayerIpsenClovis OncologyRocheAstellas Pharma USLEO Pharma Research FoundationPfizer
KeywordsMedicinePembrolizumabCarboplatinGemcitabineChemotherapyOncologyInternal medicineMetastatic Urothelial CarcinomaUrothelial carcinomaPopulationCisplatinCancerImmunotherapyBladder cancer
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.012
Threshold uncertainty score0.039
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.002 |
| Meta-epidemiology (narrow) | 0.003 | 0.001 |
| Meta-epidemiology (broad) | 0.004 | 0.004 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.005 |
| Insufficient payload (model declined to judge) | 0.012 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.101
GPT teacher head0.410
Teacher spread0.309 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations648
Published2021
Admission routes1
Has abstractno