The Effect of Morbid Obesity or Advanced Maternal Age on Oxytocin-induced Myometrial Contractions: An In Vitro Study
Bibliographic record
Abstract
(Can J Anesth. 2020;67:836–846) Worldwide, the rate of pregnant women who are of advanced maternal age (AMA) or who are overweight or morbidly obese is rising. These factors are associated with higher rates of labor induction or augmentation, prolonged labor, cesarean delivery and postpartum hemorrhage (PPH). Oxytocin is used both to prevent and treat PPH and for labor induction and augmentation. However, when oxytocin use is prolonged, a phenomenon known as oxytocin receptor desensitization can occur. This desensitization weakens the contractile response to repeated oxytocin treatment and can lead to severe PPH. The aim of this study was to investigate in vitro the effect of oxytocin on myometrial contractions in pregnant women with AMA and morbid obesity.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".