The Effect of Morbid Obesity or Advanced Maternal Age on Oxytocin-induced Myometrial Contractions: An In Vitro Study
Bibliographic record
Abstract
( Can J Anesth . 2020;67:836–846) Worldwide, the rate of pregnant women who are of advanced maternal age (AMA) or who are overweight or morbidly obese is rising. These factors are associated with higher rates of labor induction or augmentation, prolonged labor, cesarean delivery and postpartum hemorrhage (PPH). Oxytocin is used both to prevent and treat PPH and for labor induction and augmentation. However, when oxytocin use is prolonged, a phenomenon known as oxytocin receptor desensitization can occur. This desensitization weakens the contractile response to repeated oxytocin treatment and can lead to severe PPH. The aim of this study was to investigate in vitro the effect of oxytocin on myometrial contractions in pregnant women with AMA and morbid obesity.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".