Vericiguat in the management of heart failure with reduced ejection fraction
Bibliographic record
Abstract
Data from contemporary clinical trials have led to a multi-target approach aimed at the various pathophysiological mechanisms implicated in heart failure (HF). One of these pathways is the cyclic guanosine monophosphate (cGMP) signalling cascade, which forms the basis for the use of nitrates in heart failure with reduced ejection fraction (HFrEF). Under physiological conditions, nitric oxide (NO) is released by the vascular endothelium and catalyses soluble guanylate cyclase (sGC)-mediated cGMP production. An intracellular signalling cascade ensues, leading to decreased ventricular remodelling, myocardial thickening, fibrosis, and vascular constriction. This pathway becomes disrupted in HF as endothelial dysfunction and oxidative stress result in decreased NO bioavailability and cGMP production.1 As such, vericiguat, a direct sGC stimulator which also sensitizes sGC to NO, has been studied as a therapeutic option in patients with chronic HFrEF. The Soluble Guanylate Cyclase Stimulator in Heart Failure with Reduced Ejection Fraction Study (SOCRATES-REDUCED) was a Phase...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".