Nitric oxide and renal haemodynamics during postnatal maturation: Role of angiotensin receptors
Bibliographic record
Abstract
To investigate whether renal haemodynamic effects of nitric oxide (NO) in the newborn are mediated by activation of angiotensin type 1 (AT 1 ) or/and type 2 (AT 2 ) receptors, three experiments were carried out in conscious, chronically instrumented lambs aged ~one (N=5) and ~six weeks (N=6). Measurements were made before and after I.V. administration of antagonists selective to the AT 1 receptor (ZD 7155, experiment 1), the AT 2 receptor (PD 123319, experiment 2), and both receptors (ZD 7155+PD 123319, experiment 3) before and after administration of the L‐arginine analogue, L‐NAME. After ZD 7155 and ZD 7155+PD 123319, but not PD 123319 alone, renal vascular resistance (RVR) decreased in both age groups by ~25%. At one week, the RVR increase after L‐NAME was ~20% with ZD 7155, and ZD 7155 plus PD 123319, and ~16% with PD 123319 alone. At six weeks, the RVR increase after L‐NAME was ~40% with ZD 7155, and ZD 7155+PD 123319, and ~30% with PD 123319 alone. Therefore, ANG II modulates baseline renal haemodynamics as well as the renal haemodynamic effects of NO in an age‐dependent manner, through activation of both AT 1 and AT 2 receptors.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".