Several PDE4‐family enzymes differentially regulate EPAC1‐mediated actions during VEC tubule formation
Bibliographic record
Abstract
Studies have established that several angiogenesis‐related actions of vascular endothelial cells (VECs) are differentially affected by cAMP‐elevating agents. This selectivity is coordinated, in part, by actions of cAMP at individual VEC cAMP‐signaling complexes. Indeed, recently we showed that EPAC1‐integration into a phosphodiesterase 3B (PDE3B)‐based VEC cAMP‐signalosome allows PDE3 inhibitors to activate PI3Kã and promote VEC adhesion to matrigel, an early event in tubules formation. Since EPAC1 integrates into a PDE4D‐containing, VE‐cadherin‐based, cAMP signalosomes that allows EPAC1 to control VEC intercellular contacts, but not adhesions, we investigated how PDE4 inhibitors impacted VEC tubule formation. Our findings identify distinct roles for each PDE4B and PDE4D in the control of EPAC1‐mediated effects in tubule formation and identify potential novel therapeutic strategies to control these angiogenesis‐related events.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".