Sensing of intracellular Hcp levels controls T6SS expression in <i>Vibrio cholerae</i>
Bibliographic record
Abstract
Significance Assembly, firing, and recycling of the type 6 secretion system (T6SS) organelle is a costly process as each secretion event ejects hundreds of inner-tube Hcp molecules. In comparison to bacteria whose T6SSs are tightly regulated, bacterial strains that constitutively display T6SS activity would seem inefficient in their deployment of T6SS, especially if secretion is interrupted by environmental conditions that reduce available cellular energy. Here we have discovered a quantity-sensing feedback control that avoids wasteful accumulation of secreted proteins in several pathogens that express the T6SS. By sensing the efficiency of secretion of its major substrate (Hcp), this regulatory mechanism likely conserves energy and would therefore be helpful in responding to a variety of stress conditions that interrupt T6SS secretion.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".