Evaluation of antioxidant, membrane stabilizing, antimicrobial, cytotoxic and thrombolytic properties of the crude extracts of Stixis suaveolens growing in Bangladesh
Why this work is in the frame
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Bibliographic record
Abstract
The current study was conducted to investigate anti-oxidative, membrane stabilizing, antimicrobial, cytotoxic and thrombolytic properties of Methanol, Aqueous, Pet-Ether, Dichloromethane, and Ethyl Acetate soluble fractions of Stixis suaveolens. To determine the antioxidant activity, free radical scavenging activities (antioxidant capacity) of the plant extracts on the stable radical 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and total phenolic content was determined. Ascorbic Acid & BHT were used as standards in this studies. To evaluate cytotoxicity, the brine shrimp lethality bioassay was used.Vincristine sulfate (VS) was used as positive control. Antithrombolytic ability of the plant extracts were determined on bloods drawn from healthy volunteers. Membrane stabilizing potential were assessed by evaluating their ability to inhibit haemolysis of human erythrocytes. Antimicrobial investigation by disc diffusion method revealed no anti-microbial potential. The amount of total phenolic content differed in different extractives and ranged from 4.9375mg of GAE/gm of extractives to 70.125mg of GAE/gm of extractives of Fruits of S. suaveolens Roxb. The antioxidant activity of IC50 values in DPPH method are differed in different extractives and ranged from (75.67μg/ml) to (5634.00μg/ml). Methanol Soluble Fraction (MESFF) of Fruits of S. suaveolens Roxb. exhibited highest thrombolytic activity of 26.85%. Furthermore, the Aqueous Soluble Fraction (AQSF) inhibited 11.06%, Ethyl Acetate Soluble Fraction (EASF) inhibited 9.16%, Methanol Soluble Fraction (MESF) inhibited 8.84%, Dichloromethane Soluble Fraction (DCMSF) inhibited 7.92%, and Pet-Ether Soluble Fraction (PESF) inhibited 5.86% of hemolysis of RBC. The highest brine shrimp lethality was given by EASF with 0.99μg/ml followed by PESFwith 1.10μg/ml, DCMSFwith 4.77μg/ml, MESF with 8.37μg/ml and AQSFwith 24.26μg/ml. Hence, that S. suaveolens extracts and its fractions possess anti-oxidant, membrane stabilizing, cytotoxic and thrombolytic properties.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.004 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it