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Record W3167136803 · doi:10.1016/j.cgh.2021.06.011

Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study

2021· article· en· W3167136803 on OpenAlexfundno aff
Silvio Danese, Maria Kłopocka, Ellen Scherl, Jacek Romatowski, Jessica R. Allegretti, Elena Peeva, Michael S. Vincent, Uwe Schoenbeck, Ye Zhan, Mina Hassan‐Zahraee, Natalie Rath, Gang Li, Srividya Neelakantan, Christopher Banfield, Christopher Lepsy, Deepa E. Chandra, Kenneth E. Hung

Bibliographic record

VenueClinical Gastroenterology and Hepatology · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsnot available
FundersJanssen Research and DevelopmentUniversity of California, San FranciscoGenentechFerring PharmaceuticalsUCBBiogenNational Institute of Diabetes and Digestive and Kidney DiseasesSeres TherapeuticsHospiraJohns Hopkins UniversityBoehringer IngelheimJanssen PharmaceuticalsCMC MicrosystemsGilead SciencesAbbVieAbbott LaboratoriesMerckCrohn's and Colitis Foundation of AmericaAstraZenecaPfizer
KeywordsMedicineUlcerative colitisInternal medicineGastroenterologyInflammatory bowel diseaseCalprotectinAdverse effectPopulationTolerabilityImmunologyDisease

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.013
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.029
GPT teacher head0.365
Teacher spread0.336 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations91
Published2021
Admission routes1
Has abstractno

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