MétaCan
Menu
Back to cohort
Record W3167479850 · doi:10.1038/s41592-021-01143-1

The emerging landscape of single-molecule protein sequencing technologies

2021· review· en· W3167479850 on OpenAlexafffund
Javier A. Alfaro, Peggy R. Bohländer, Mingjie Dai, Mike Filius, Cecil J. Howard, Xander F. van Kooten, Shilo Ohayon, Adam Pomorski, Sonja Schmid, Aleksei Aksimentiev, Eric V. Anslyn, Georges Bedran, Chan Cao, Mauro Chinappi, Étienne Coyaud, Cees Dekker, Gunnar Dittmar, Nicholas Drachman, Rienk Eelkema, David R. Goodlett, Sébastien Hentz, Umesh Kalathiya, Neil L. Kelleher, Ryan Kelly, Zvi Kelman, Sung Hyun Kim, Bernhard Küster, David Rodríguez‐Larrea, Stuart Lindsay, Giovanni Maglia, Edward M. Marcotte, John P. Marino, Christophe Masselon, Michael Mayer, Patroklos Samaras, Kumar Sarthak, Lusia Sepiashvili, Derek Stein, Meni Wanunu, Mathias Wilhelm, Peng Yin, A. MELLER, Chirlmin Joo

Bibliographic record

VenueNature Methods · 2021
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAdvanced biosensing and bioanalysis techniques
Canadian institutionsSickKids FoundationHospital for Sick ChildrenUniversity of TorontoUniversity of Victoria
FundersNational Institute of Biomedical Imaging and BioengineeringNational Institute of General Medical SciencesNational Cancer InstituteNational Institute of Standards and TechnologyNarodowa Agencja Wymiany AkademickiejArmy Research OfficePeter und Traudl Engelhorn StiftungIsrael Science FoundationNational Human Genome Research InstituteAgence Nationale de la RechercheNederlandse Organisatie voor Wetenschappelijk OnderzoekNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungEuropean Regional Development FundHansjörg Wyss Institute for Biologically Inspired Engineering, Harvard UniversityFundacja na rzecz Nauki PolskiejEuropean CommissionGenome British ColumbiaGenome CanadaRégion Hauts-de-FranceNational Institute of Diabetes and Digestive and Kidney DiseasesMichael J. Fox Foundation for Parkinson's ResearchNational Science Foundation
KeywordsComputational biologyProfiling (computer programming)ProteomeBiologySingle-cell analysisTranscriptomeGenomeCellBioinformaticsComputer scienceGeneticsGeneGene expression

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.005
Threshold uncertainty score0.018

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0020.002
Science and technology studies0.0000.001
Scholarly communication0.0020.003
Open science0.0020.001
Research integrity0.0020.003
Insufficient payload (model declined to judge)0.0050.004

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.408
Teacher spread0.377 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations362
Published2021
Admission routes2
Has abstractno

Explore more

Same venueNature MethodsSame topicAdvanced biosensing and bioanalysis techniquesFrench-language works237,207