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Record W3167479850 · doi:10.1038/s41592-021-01143-1

The emerging landscape of single-molecule protein sequencing technologies

2021· review· en· W3167479850 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueNature Methods · 2021
Typereview
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicAdvanced biosensing and bioanalysis techniques
Canadian institutionsSickKids FoundationHospital for Sick ChildrenUniversity of TorontoUniversity of Victoria
FundersNational Institute of Biomedical Imaging and BioengineeringNational Institute of General Medical SciencesNational Cancer InstituteNational Institute of Standards and TechnologyNarodowa Agencja Wymiany AkademickiejArmy Research OfficePeter und Traudl Engelhorn StiftungIsrael Science FoundationNational Human Genome Research InstituteAgence Nationale de la RechercheNederlandse Organisatie voor Wetenschappelijk OnderzoekNational Institutes of HealthSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungEuropean Regional Development FundHansjörg Wyss Institute for Biologically Inspired Engineering, Harvard UniversityFundacja na rzecz Nauki PolskiejEuropean CommissionGenome British ColumbiaGenome CanadaRégion Hauts-de-FranceNational Institute of Diabetes and Digestive and Kidney DiseasesMichael J. Fox Foundation for Parkinson's ResearchNational Science Foundation
KeywordsComputational biologyProfiling (computer programming)ProteomeBiologySingle-cell analysisTranscriptomeGenomeCellBioinformaticsComputer scienceGeneticsGeneGene expression

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.877
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0020.001
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.408
Teacher spread0.377 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it