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Record W3167673380 · doi:10.15562/gnc.75

Applications of Stem Cells in Cancer Therapy: A Literature Based Studies

2020· article· en· W3167673380 on OpenAlexvenueno aff
Sara Javed, Fatima Ali, Nadia Wajid

Bibliographic record

VenueJournal of Genes and Cells · 2020
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicPluripotent Stem Cells Research
Canadian institutionsnot available
Fundersnot available
KeywordsStem cellCancer stem cellRegeneration (biology)Retinitis pigmentosaStem-cell therapyCancerBiologyRegenerative medicineCell lineageCancer cellMedicineCellular differentiationCancer researchNeuroscienceCell biologyRetinaGenetics

Abstract

fetched live from OpenAlex

Stem cells, are extraordinary kind of cells having unique ability of self-renewal, lineage differentiation and regeneration of damaged organ or parts of body. Stem cells experience asymmetric cell divisions, bringing forth two cells from each cell, one cell is alike to SCs in stemnessess whereas, other is differentiated into various lineage. These cells have been known for decades for their highest regenerative potential but their clinical applications remain delayed due to several unknown mechanisms of their actions. With the discovery of Cancer Stem Cells, it was described that understanding the stem cell biology is important for a proper way of cancer cure. Stem cells are successfully being transplanted in several clinical trials to treat the retinal disease, visual disorders including retinitis pigmentosa, Stargardt's disease, wound healing, skin regeneration and age related macular degeneration. Their role in cancer progression is the hot debate of research by cell biologists as understanding their role will help to remove the hurdles in cancer therapy.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.067
Threshold uncertainty score0.231

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.028
GPT teacher head0.305
Teacher spread0.278 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2020
Admission routes1
Has abstractyes

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