Quantification of perfusion in mouse ovarian grafts for fertility preservation
Bibliographic record
Abstract
A serious side effect for some young women undergoing cancer treatment is premature ovarian failure and sterility. To preserve fertility ovarian cortex may be harvested, cryogenically preserved and re‐implanted in patients who return to full health. In the absence of vascular anastomosis, tissue is ischemic and the grafting will only be successful if there is rapid reperfusion to minimize loss of follicles. As a model of the clinical procedure, mouse ovaries were grafted to skeletal muscle and monitored non‐invasively using MicroMarker contrast agent and high‐frequency ultrasound (Vevo770, VisualSonics). Vascular perfusion and relative blood volume approached the levels of intact ovaries after seven days. The results demonstrate that microultrasound can monitor reperfusion in small ischemic grafts and is potentially useful for studying the effects of drugs and hormones as well as measuring the progress of angiogenesis. The study was funded by VisualSonics Inc.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".