Temperature regulation of fish‐specific paralogs of cardiac TnC
Bibliographic record
Abstract
Temperature‐dependent regulation of factors involved with cardiac contractility is crucial for ectothermic fish facing changes in temperature. The teleost‐specific whole genome duplication created multiple copies of genes allowing for sub‐functionalization of isoforms. The Ca2+‐binding troponin C (TnC), responsible for initiating myocyte contraction is highly conserved across vertebrates due to its crucial role in regulating contractility. TnC expressed in the hearts of many teleosts is the product of two distinct genes: cardiac TnC (cTnC) and the fish‐specific slow skeletal TnC (ssTnC). Tissue‐specific mRNA profiles in adult zebrafish revealed a distinct localization of gene expression, with ssTnC preferentially expressed in the atrium and cTnC is almost exclusively expressed in the ventricle. Chamber‐specific localization varies between teleost species, with trout preferentially expressing cTnC in both chambers of the heart. Isoform composition of the chambers is also modulated by changes in temperature. Possible sub‐functionalization of TnC isoforms may provide insight into how teleosts achieve physiological versatility in chamber‐specific contractile properties. Funded by NSERC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".