<i>ALOX5</i> gene variations modulate plasma triglyceride levels during an n‐3 polyunsaturated fatty acid supplementation
Bibliographic record
Abstract
Single nucleotide polymorphisms (SNPs) in the arachidonate 5‐lipoxygenase ( ALOX5 ) gene may play a role in lowering plasma triglyceride (TG) levels following supplementation with omega‐3 (n‐3) polyunsaturated fatty acids (PUFA). Objective To examine the effects of n‐3 PUFA supplementation on plasma TG levels in relation to the presence of SNPs in the ALOX5 gene. Methods 208 subjects completed a 2‐wk run‐in period followed by a 6‐wk supplementation with 5g/d of fish oil (1.9g of EPA + 1.1g of DHA). Genotyping of 12 SNPs of the ALOX5 gene was performed covering 86% of common genetic variations (minor allele frequency ≥0.05). Results Gene*diet interaction effects were observed for plasma TG (rs1565096 and rs7913948). Significant differences in TG levels were observed for SNP rs1565096 where AA homozygotes (HMZ) showed a smaller reduction of plasma TG levels as compared to GG HMZ (p=0.04). Conclusion Results suggest that SNPs in the ALOX5 gene may modulate plasma TG levels in response to n‐3 PUFA supplementation. Funding : FAST‐NSERC
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".