Alteration of endothelial CaMKII in AngII‐induced hypertensive mice
Bibliographic record
Abstract
Endothelial dysfunction found in AngII‐induced hypertension is characterized by an alteration of the delicate balance between reactive oxygen species (ROS) and nitric oxide (NO). Loss of endothelial Ca 2+ homeostasis has also been shown in hypertension. Recent evidences suggest that CaMKII is activated by Ca 2+ pulsars, a localized spontaneous Ca 2+ signal and is involved in endothelial function. Since CaMKII is also sensitive to intracellular ROS, endothelial CaMKII and Ca 2+ pulsars in an AngII‐induced hypertension mouse model was studied. Real‐time confocal imaging showed that acute exposure to AngII stimulated both Ca 2+ pulsars and production of ROS. As expected, an increase in endothelial ROS production was found with dihydroethidium (DHE) in the AngII hypertensive compared to normotensive mice. Moreover, AngII‐induced hypertension appears to recruit activated CaMKII (T286) at the myoendothelial projection (MEP), sites of Ca 2+ pulsars. Consistently, clustering of all endothelial CaMKII isoforms (α, β and δ) within the MEP has showed a similar distribution. Our data suggest that CaMKII activity is modulated by an increased ROS production and Ca 2+ pulsars stimulation in AngII‐induced hypertensive mice. Supported by CIHR, FRQS, CFI and HSFC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".