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Record W3171542065 · doi:10.1017/cjn.2021.97

The Amygdala in Neurodegeneration

2021· article· en· W3171542065 on OpenAlexaffvenue
JT Joseph

Bibliographic record

VenueCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · 2021
Typearticle
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsUniversity of Calgary
Fundersnot available
KeywordsAmygdalaNeurodegenerationNeuroscienceDiseasePathologicalAlzheimer's diseaseMedicinePsychologyPathology

Abstract

fetched live from OpenAlex

The amygdala is a key anatomic structure that has multiple different nuclei and is involved in several critical aspects of cognition and systemic functions. Several different neurodegenerative diseases have major pathological effects on distinct amygdala nuclei. This presentation will describe the classic and characteristic anatomic distributions in the amygdala of “pure” Alzheimer disease and “pure” Lewy body disease, as well as “normal aging”. In addition, data will be presented on how these classic distributions are altered in either “mixed dementias” or in some atypical forms of neurodegeneration. Amygdala pathology will also be illustrated in several other neurodegenerative diseases. The implications of the differing anatomic distributions in different neurodegenerative diseases will be discussed. LEARNING OBJECTIVES This presentation will enable the learner to: Recognize key anatomic divisions of the amygdala 1. Describe how different neurodegenerative diseases affect the amygdala 2. Consider how anatomic specificity of protein aggregation is important in the classification of neurodegenerative diseases

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.007
Threshold uncertainty score0.024

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.000
Science and technology studies0.0010.003
Scholarly communication0.0020.003
Open science0.0010.002
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0070.002

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.048
GPT teacher head0.312
Teacher spread0.264 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes2
Has abstractyes

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