Impaired endothelium‐dependent vasorelaxation contributes to hypertension in leukocyte‐specific protein 1 (LSP1)‐deficient mice
Bibliographic record
Abstract
LSP1 is an intracellular, Ca2+‐and F‐actin‐binding protein expressed in leukocytes and endothelial cells. Adult male LSP1‐deficient (Lsp1−/−) mice had higher blood pressure than their WT counterparts. By Western blot, LSP1 was found present in aorta and mesenteric artery tissues in WT mice but not in Lsp1−/− mice. The role of LSP1 in regulating arterial vascular tone was studied. The contraction of aorta and mesenteric arteries in response to phenylephrine and angiotensin II was similar in WT and Lsp1−/− mice. The relaxation of aorta artery was more sensitive to sodium nitroprusside and methacholine in Lsp1−/− mice than in WT mice. The phenylephrine‐constricted mesenteric arteries showed identical relaxation curve to sodium nitroprusside in these two strains of mice, but had no relaxation to methacholine in Lsp1−/− mice or in denuded WT mesenteric arteries. Methacholine‐induced mesenteric arterial relaxation in WT mice was suppressed partially by the pretreatment of L‐NAME or the combination of apamin + TRAM‐34, abolished completely by the combination of L‐NAME + apamin + TRAM‐34, but not changed by indomethacin. Our results demonstrate the defects in endothelium‐dependent vasorelaxation in resistance arteries in mice deficient in LSP1 revealing an important role for LSP1 in endothelium‐dependent vasodilation in small resistance arteries and blood pressure regulation.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".