2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
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- Teacher spread
- 0.353 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
OBJECTIVE: To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. METHODS: We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising clinicians and patients achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations. RESULTS: The guideline addresses treatment with disease-modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs, biologic DMARDs, and targeted synthetic DMARDs, use of glucocorticoids, and use of DMARDs in certain high-risk populations (i.e., those with liver disease, heart failure, lymphoproliferative disorders, previous serious infections, and nontuberculous mycobacterial lung disease). The guideline includes 44 recommendations (7 strong and 37 conditional). CONCLUSION: This clinical practice guideline is intended to serve as a tool to support clinician and patient decision-making. Recommendations are not prescriptive, and individual treatment decisions should be made through a shared decision-making process based on patients' values, goals, preferences, and comorbidities.
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The record
- Venue
- Arthritis Care & Research
- Topic
- Rheumatoid Arthritis Research and Therapies
- Field
- Medicine
- Canadian institutions
- Toronto Western HospitalUniversity of TorontoMount Sinai Hospital
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- Keywords
- MedicineGuidelineRheumatoid arthritisIntensive care medicinePhysical therapyRheumatologyRituximabInternal medicineAntirheumatic AgentsPathologyLymphoma
- Has abstract in OpenAlex
- yes