Effect of nitrous oxide (N2O) explosure during surgery on homocysteine (Hcy) concentrations of children
Bibliographic record
Abstract
Postoperative acute hyperhomocysteinemia has been associated with an increased risk of complications in adults. In this study we determined the effect of N 2 O on the Hcy concentrations of children and whether blood levels of folate vitamin B12, B6, methylmalonic acid (MMA) and methylenetetrahydrofolate reductase C6777T genotype affected this relationship. Total Hcy was measured before and after N 2 O. Vitamin levels, MMA and genotype were determined preoperatively. Median age of the 32 participants was 11mo. (3–126mo.). All children had folate and B6 levels above cut‐off values (7.4; 31nmol/L respectively). Five children had MMA levels above cut‐off (≥ 0.23μmol/L). Post‐exposure Hcy increased by 25% ( P = <0.001). Length of exposure was strongly associated with the increase (r=0.696, P =<0.001). There was a trend between vitamin B12 and Hcy increase (r = − 0.450, P =0.080). Folate, vitamin B6 and genotype had no effect on Hcy. In conclusion, Hcy increases after exposure to N 2 O in children. Studies investigating clinical relevance of the increase and benefit of pre‐surgical vitamin B12 supplementation may prove worthwhile. Funding: Mead Johnson/Heinz/Weston Endowment for Nutrition/Metabolism Research; CONACYT.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".