Estrogen and progesterone do not mediate the attenuated febrile response to E. coli LPS in rats near the term of pregnancy
Bibliographic record
Abstract
The febrile response to LPS is attenuated in rats near the term of pregnancy at a time when plasma concentrations of estrogen (E) and progesterone (P) are elevated. In an attempt to clarify mechanisms, the present experiments were carried out on chronically‐instrumented, conscious rats to test the hypothesis that elevated plasma concentrations of E and P similar to that observed near the term of pregnancy would attenuate the febrile response to LPS in non pregnant rats (NP). NP and oophorectimized rats received intraperitoneal vehicle (V) or E, P, E+P over 3.5 days in amounts sufficient to produce plasma concentrations observed near the term of pregnancy. Core temperature was recorded via radio telemetry. Hormone treatment did not alter basal core temperatures nor the core temperature responses to an EC 50 dose of E. coli LPS. Thus, our data do not support the hypothesis that elevated plasma concentrations of E & P mediate the attenuated core temperature responses to LPS in rats near the term of pregnancy.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".