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Record W3173178658 · doi:10.1039/d1na00055a

Interaction of Tau construct K18 with model lipid membranes

2021· article· en· W3173178658 on OpenAlexafffund
Mehdi Azouz, Cécile Feuillie, Michel Lafleur, Michaël Molinari, Sophie Lecomte

Bibliographic record

VenueNanoscale Advances · 2021
Typearticle
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsUniversité de Montréal
FundersH2020 Marie Skłodowska-Curie ActionsUniversité de BordeauxUniversité de MontréalAgence Nationale de la RechercheDeutsches Zentrum für Neurodegenerative ErkrankungenFonds Québécois de la Recherche sur la Nature et les TechnologiesCHIST-ERANatural Sciences and Engineering Research Council of CanadaEuropean Commission
KeywordsNeurodegenerationChemistryMembraneBiophysicsProtein aggregationTau proteinLipid bilayerCell biologyFibrilProtein foldingBiochemistryAlzheimer's diseaseBiologyDisease

Abstract

fetched live from OpenAlex

AFM imaging of model membranes of controlled composition in interaction with Tau construct K18 showed PIP <sub>2</sub> induced K18 fibrillization.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.841
Threshold uncertainty score0.292

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.318
Teacher spread0.298 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations15
Published2021
Admission routes2
Has abstractyes

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