A Wavelet-Based Approach for Estimating Time-Varying Connectivity in Resting-State Functional Magnetic Resonance Imaging
Bibliographic record
Abstract
Introduction: The selection of an appropriate window size, window function, and functional connectivity (FC) metric in the sliding window method is not straightforward due to the absence of ground truth. Methods: A previously proposed wavelet-based method was accordingly adjusted for estimating time-varying FC (TVFC) and was applied to a large high-quality, low-motion dataset of 400 resting-state functional magnetic resonance imaging data. Specifically, the wavelet coherence magnitude and relative phase were averaged across wavelet (frequency) scales to yield TVFC and synchronization patterns. To assess whether the observed fluctuations in TVFC were statistically significant (dynamic FC [dFC]; the distinction between TVFC and dFC is intentional), surrogate data were generated using the multivariate phase randomization (MVPR) and multivariate autoregressive randomization (MVAR) methods to define the null hypothesis of dFC absence. Results: By averaging across all frequencies, core regions of the default mode network (DMN; medial prefrontal and posterior cingulate cortices, inferior parietal lobes, hippocampal formation) were found to exhibit dFC (test–retest reproducibility of 90%) and were also synchronized in activity (−15° ≤ phase ≤15°). When averaging across distinct frequency bands, the same dynamic connections were identified, with the majority of them identified in the frequency range (0.01, 0.198) Hz, though with lower test–retest reproducibility (<66%). Additional analysis suggested that MVPR method better preserved properties (p < 10−10), including time-averaged coherence, of the original data compared with MVAR approach. Conclusions: The wavelet-based approach identified dynamic associations between the core DMN regions with fewer choices in parameters, compared with sliding window method. We employed a wavelet-based method, previously used in the literature, and proposed modifications to assess time-varying functional connectivity in resting-state functional magnetic resonance imaging. With this approach, dynamic connections within the default mode network were identified, involving the medial prefrontal and posterior cingulate cortices, inferior parietal lobes, and hippocampal formation, which were also highly consistent in test–retest analysis (test–retest reproducibility of 90%), without the need to select window size, window function, and functional connectivity metric as with the sliding window method, whereby no consensus on the appropriate choices of hyperparameters currently exists in the literature.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.005 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".