Role of interleukin‐33 in sepsis‐induced myocardial dysfunction
Bibliographic record
Abstract
The disruption of myocardial extracellular matrix (ECM) protein has been implicated in myocardial dysfunction during sepsis. However, the underlying mechanism(s) are not clear. Interleukin‐ 33 (IL‐33) is a cytokine which can regulate collagen synthesis in various cardiac pathologies. The purpose of the present study is to test whether IL‐33 contributes to the sepsis‐induced myocardial dysfunction through regulation of matrix metalloprotease‐9 (MMP‐ 9). Methods In vivo, feces‐induced peritonitis (FIP) in mice and in vitro LPS treatments to isolated cardiomyocytes were used in the study. Results In mice with FIP, myocardial IL‐33 and MMP‐9 expression were increased and myocardial contractility was decreased. Myocardial function in mice with FIP was improved when the mice were treated with soluble ST2 (sST2), a decoy receptor of IL‐33. The in vitro, expression of IL‐33 and MMP‐9 in cardiomyocytes treated with LPS was increased. Addition of sST2 prevented the increase in MMP‐9 expression in LPS treated myocytes. Conclusion Our results indicate IL‐33 plays an important role in mediating sepsis‐induced myocardial dysfunction by regulation of myocyte MMP‐9 expression. (Supported by the Department of National Defense, Canadian Forces Medical Group)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".