Splenic neural modulation of mesenteric vascular tone
Bibliographic record
Abstract
Portal hypertension impedes outflow from the splanchnic vascular beds. We hypothesized that the increase in splenic intravascular pressure may initiate a neural reflex to increase mesenteric arterial tone and reduce blood flow into the plethoric mesenteric vascular bed. Splenic venous pressure was selectively increased by partial splenic vein occlusion (6.9±0.5 to 22.5±0.3 mmHg, n=47). During the 3 minutes following occlusion, mesenteric vascular conductance fell (−0.01±0.002 mmHg/mL·min ‐1 ; p<0.05 n=7), an effect which was unchanged by renal denervation (−0.01±0.009 mmHg/mL·min ‐1 ; n=6) and exacerbated by mesenteric denervation (−0.02±0.004 mmHg/mL·min ‐1 ; p<0.05, n=7). The fall in conductance was abolished by splenic denervation (−0.002±0.002 mmHg/mL·min ‐1 ; p<0.05 n=6). Similarly, the significant increase in mesenteric efferent nerve activity observed during splenic venous occlusion (22.2±2.8 to 27.9±3.8 spikes/sec, p<0.05 n=13) was absent after splenic denervation (32.4±2.4 to 31.2±1.6 spikes/sec, n=7). Although the spleen is thus integral to initiating the reflex, the accompanying increase in mesenteric nerve activity is not wholly responsible for increasing mesenteric arterial tone. (HSFC,CIHR).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".