Deletion of apolipoprotein E gene substantially alters immune function in the mouse
Bibliographic record
Abstract
Objective The objective of this study was to investigate the role of apolipoprotein E in regulating immune function in the mouse. Material and Methods Male apolipoprotein E‐knockout (apo E‐KO, n= 7) mice and their wild type counterparts (C57BL, n= 9 ) were used. The animals were immunized with ovalbumin 5 days before sacrifice. The spleenocytes from both groups of mice were cultured and stimulated by ovalbumin (1000 μg/ml), and several pro‐ and anit‐inflammatory markers were measured. Results Our data are summarized in the following Table: Conclusions Our data suggest that apo E modifies immune system. Our present data plus previous findings of in vivo upregulation of IL‐12 production endorse that impaired immune function in apo E‐KO mice may be one of the major contributing factors for accelerated atherogenesis in this animal model.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".