Relapse of clinical symptoms in the acute experimental autoimmune encephalomyelitis (EAE) is adrenalectomy (ADX) time dependent in the Lewis rat
Bibliographic record
Abstract
Susceptible Lewis rats to acute experimental autoimmune encephalomyelitis (EAE) develop a single episode of paralysis, spontaneous recovery and remain refractory to EAE re‐immunizations. In non‐susceptible rats, EAE induces a strong corticosterone (CO) response protecting against the disease, whereas in the susceptible Lewis rats an inappropriate CO response induces an altered immune response. Here we study the critical time in which CO induce the refractivity to relapses in the EAE by using Lewis EAE‐adrenalectomized (ADX) animals operated at different times of EAE‐immunization. Animals were immunized with guinea pig brain homogenate in CFA (200 μL subcutaneously). Results All animals developed an acute episode of EAE symptoms which started at 10–11 days post immunization (DPI), however differences in the clinical course were apparent in the several groups. The Control group developed a single full‐blown disease without relapse. ADX 15 days before immunization and ADX 3 DPI groups developed a lethal form of EAE. ADX 20 DPI group developed a single full‐blown of EAE without relapse. ADX 27 DPI group developed the acute full‐blown symptoms with a full‐blown relapse. ADX 30 DPI group developed a mild but prolonged relapse. The ADX 36 DPI group developed a single full‐blown disease without relapse. Results indicate that there is a critical period (between 20–27 DPI), in which CO suppress the relapses of the EAE. Supported by UAA‐PIBB11–5 and CONACYT‐62317. México.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".