Analyses of the craniofacial skeleton of a zebrafish lens degeneration mutant
Bibliographic record
Abstract
The zebrafish mutant, bumper , is characterized as having a lens defect, which begins at 4dpf. Previous work has shown that in the blind morph of Astyanax mexicanus , which also has a lens defect, the ocular skeleton is affected. The ocular skeleton of sighted Astyanax mexicanus and wildtype Danio rerio consists of two scleral ossicles joined by scleral cartilage. In the blind tetra morph, however, the scleral cartilage is persistent and is not replaced by bone. In this study, homozygous and heterozygous bumper mutants of Danio rerio were analyzed. Whole‐mount analyses show that the ocular skeleton is unaffected in this mutant, unlike in blind tetras. Surprisingly, however, several other regions of the craniofacial skeleton are affected; these include the jaws and skull vault. The significance of these results is discussed with respect to the nature and timing of eye degeneration in the two species analyzed. Funding: NSERC, Canada Grant Funding Source NSERC, Canada
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.002 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".