Chronic elevation of corticosterone increases the ventilatory response to hypoxia in adult rats
Bibliographic record
Abstract
Early life exposure to a stressor such as neonatal maternal separation (NMS) disrupts the normal functioning of the hypothalamo‐pituitary‐adrenal axis and results in chronic elevation of plasma corticosterone level in the adult rat. NMS alone has several functional outcomes including an increase in the hypoxic chemoreflex through mechanisms that remain unknown (Genest et al., 2004). In the present study, we hypothesized that chronic increase of plasma corticosterone alone can amplify the ventilatory response to hypoxia in adult rats. To test this, three groups of Sprague Dawley® male rats were used (i.e. control, sham, corticosterone implants). Rats subjected to chronic plasma corticosterone elevation received subcutaneously 300 mg of corticosterone implant 14 days prior to ventilatory measurements, whereas sham‐operated rats received placebo implants instead. Blood samples taken shortly after the experiments confirmed the efficiency of our protocol. Each group underwent a single session of plethysmographic measurement of respiratory activity under normoxic followed by hypoxic conditions (12%O 2 , 20 min). Rats implanted with corticosterone showed a ventilatory response to hypoxia significantly higher than sham and control rats. These data show that a chronic elevation of corticosterone increases the ventilatory response to hypoxia and suggest that chronic corticosterone elevation alone can contribute to the respiratory phenotype observed in NMS rats. Supported by the Canadian Institutes of Health Research.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".