Gestational chronic intermittent hypoxia causes asymmetric growth restriction and alters cholesterol homeostasis in the liver of sprague‐dawley rats
Bibliographic record
Abstract
This study was done to investigate the effect of chronic intermittent hypoxia (CIH) during gestation on the development of offspring. Female Sprague‐Dawley rats were mated, housed individually, and kept on a standard rat chow diet during the study. Pregnant females (n=8) were exposed daily to CIH (6.5% O 2 nadir; 18 cycles/h; 8 h/day) from gestational day‐1 to day‐20. Control (n=6) mothers were exposed similarly to room air. Postnatal day‐1 offspring from CIH mothers showed significantly lower body weights, and lower liver‐to‐body weight ratios. By 12‐wk of age, body weights of growth restricted offspring were significantly greater, as were the liver‐to‐body weight ratios. These offspring also had greater body fat deposition and elevated circulating cholesterol levels at both 6‐wk and 12‐wk of age. Western blot and qPCR analysis showed that CIH offspring had decreased protein and gene expression of markers vital for cholesterol regulation in the liver, including Liver X Receptor (LXR), ABCA1 (cholesterol efflux) and the LDL receptor (cholesterol catabolism). These data show that alteration of the maternal intrauterine environment by gestational CIH has significant consequences on the long‐term development of offspring and increases the disposition of the animals to metabolic diseases in adulthood. Supported by Heart and Stroke Foundation and Canadian Institutes of Health Research
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".