Short‐term exercise training shifts the control of sympathetic vasoconstriction in contracting skeletal muscle to the α <sub>2</sub> ‐adrenergic receptor
Bibliographic record
Abstract
We hypothesized that short‐term mild‐ (M) and heavy‐intensity (H) exercise training (ET) would augment α 2 ‐adrenergic receptor mediated vasoconstriction in skeletal muscle. Sprague‐Dawley rats (n=30) were randomized to sedentary (S), M (20m/min5% grade) or H (40m/min5% grade) ET groups and trained 5d/wk for 4 wks with equal ET volume. Rats were anesthetised and instrumented for lumbar sympathetic chain stimulation and measurement of femoral vascular conductance (FVC). Triceps surae muscles were contracted at 60% of maximal contractile force. The percent decrease in FVC to sympathetic stimulation (2 and 5 Hz) was determined at rest and during contraction before (C) and after α 2 blockade (Yohimbine; Y). ET increased (p<0.05) vasoconstrictor responsiveness. Y did not alter (p>;0.05) the decrease in FVC in S rats at rest ( C: 2Hz: −22±5% 5Hz: −36±6%; Y: 2Hz: −20±5% 5Hz: −34±6%) or during contraction ( C: 2Hz: −6±4% 5Hz: −18±5%; Y: 2Hz: −7±3% 5Hz: −16±5%). In contrast, Y reduced (p<0.05) vasoconstriction in ET rats at rest ( M: C: 2Hz: −34±4% 5Hz: −47±7%; Y: 2Hz: −26±5% 5Hz: −38±7%; H: C: 2Hz: −44±5% 5Hz: −57±8%; Y: 2Hz: −30±6% 5Hz: −46±6%) and during contraction ( M: C: 2Hz: −12±3% 5Hz: −20±3%; Y: 2Hz: −3±2% 5Hz: −11±5%; H: C: 2Hz: −12±3% 5Hz: −19±7%; Y: 2Hz: −4±3% 5Hz: −12±2%). ET increased α 2 mediated constriction and shifted the control of sympathetic vasoconstriction in contracting muscle to the α 2 receptor. NSERC, Canada.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".