Nitric oxide buffers effects of angiotensin II on arterial baroreflex control of heart rate in conscious lambs
Bibliographic record
Abstract
Previously, we showed that both nitric oxide (NO) and angiotensin II (ANG II) modulate the arterial baroreflex control of heart rate soon after birth. To test the hypothesis that NO buffers the effects of ANG II through activation of AT 1 receptors early in life, three experiments were carried out at intervals of 48 h and in random order in two age groups of conscious, chronically instrumented lambs: ∼one week (N=9) and ∼six weeks (N=11): The arterial baroreflex was assessed before and after administration of the selective AT 1 receptor antagonist, ZD 7155, and vehicle (experiment one), ZD 7155 and L‐NAME (experiment two), or vehicle alone (experiment three). There were no effects on any of the parameters governing the arterial baroreflex at six weeks after ZD 7155 with or without L‐NAME or vehicle. In contrast, after ZD 7155 at one week there was a decrease in the heart rate range, an increase in minimum heart rate, and an increase in maximum gain. After L‐NAME, in the presence of ZD 7155, these changes were exacerbated at one‐ but not six weeks. These findings support the postulate that there is an age‐dependent interaction between ANG II and NO in modulating the arterial baroreflex control of heart rate.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".