AGE‐DEPENDENT EFFECTS OF PROGESTERONE ON VENTILATION AND APNEA IN RATS
Bibliographic record
Abstract
Progesterone has been proposed as an alternative for apnea treatment in neonates but relevant data are rare. In rats aged 1, 4, 7, and 12 days we investigated the effects of progesterone (Prog, 4 mg/kg, i.p.) on baseline ventilation, hypoxic ventilatory response (HVR, 12% O2, 20 minutes), apnea frequency (for spontaneous and post‐sigh apneas), and arterial oxygen desaturation and bradycardia during apneas (Mouse‐Ox device). Control rats received a saline injection (2 ul/g i.p.). Prog had no effect on baseline ventilation, increased the peak HVR in 4 and 7 d‐old and the steady state HVR in 1, 4 and 7 d‐old, but had no effects in 12 d‐old rats. About 23% of all apneas were associated with desaturation and/or bradycardia independently of their types. Prog reduced the frequency of those apneas particularly in 1‐d‐old rats. These preliminary observations suggest that acute Prog injection stimulates HVR in rats less or equal to 7 d‐old and reduces apnea independently to its effect on HVR. Supported by Foundation of Stars.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".