Abstract 134: Association Between Kidney Size, Function and Blood Pressure in Young Adults Born Extremely Preterm
Bibliographic record
Abstract
Background: Children born extremely preterm (EPT; ≤29 weeks) have higher blood pressure (BP), lower nephron mass, and increased risk in later life of renal and cardiovascular dysfunction. Whether nephron mass and renal function impact BP in EPT subjects is unknown. We correlated BP with renal size and function in young adults born EPT vs term (T). Methods: Anthropometric measurements, serum and urine chemistry, renal ultrasound, and 24 hour ambulatory BP were obtained in 40 EPT and 40 T born young adults matched for age, sex, race, and socioeconomic status. Comparisons were made using paired T and Wilcoxon signed ranked tests and correlations using Pearson correlation. Results: Study population characteristics are in Table 1. Young adults born EPT had higher systolic BP (SBP) and diastolic BP (DBP), and smaller kidneys (Table 2). Awake SBP and DBP loads in the hypertensive range inversely correlated with kidney size only in EPT participants. Conclusion: Young adults born EPT have higher BP and smaller kidneys vs T controls. EPT young adults with smaller kidneys have a greater BP load in the hypertensive range.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".