A novel model for ischemic stroke ‐ the ANP gene disrupted (ANP−/−) mouse: molecular effects of hypertension in the development of stroke
Bibliographic record
Abstract
Cardiovascular disease (CVD) and stroke share many similar risk factors including hypertension. Alterations in the natriuretic peptide system (NPS) have shown to play a protective role in cardiac hypertrophy (CH) and myocardial infarction (MI). Given the similarities between CVD and stroke, these conditions may also share similar molecular mechanisms in their etiologies. The objective of this study is to develop a novel model for stroke using the chronically hypertensive, atrial natriuretic peptide (ANP) gene disrupted (ANP −/ − ) mouse to assess the effect of hypertension on stroke development. ANP +/− (salt‐sensitive) mice treated with either high (8%) or normal (0.8%) salt diet for 6 weeks were subjected to left middle cerebral artery occlusion (MCAO) for 30 min and allowed to recover for 24 hr. Results have demonstrated left ventricular (LV) hypertrophy and increased infarct volumes in mice treated with high dietary salt. Furthermore, we have characterized the alterations occurring in four major vasoactive systems in the brain; the NPS, the renin‐angiotensin system (RAS), the nitric oxide system (NOS) and endothelin system (ETS) using real‐time quantitative PCR (qPCR). Since ablation of ANP induces CH, understanding the molecular mechanisms of the above systems in the brain will allow us to assess if ANP plays a protective role for stroke as it does for MI. Support: HSFO and Canadian Foundation for Innovation. Grant Funding Source : Heart and Stroke Foundation of Ontario and Canadian Foundation for Innovation
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".