Role of prostaglandins in the loss of lymphatic contractile function in the experimental guinea pig model of TNBS‐induced ileitis
Bibliographic record
Abstract
The lymphatic vessel pumping is critical in maintaining tissue fluid homeostasis, particularly during edematous stress, such as inflammation. Loss of this function (i.e. dilated hyporesponsive lymphatic vessels) previously observed during experimental intestinal inflammation could be mediated by prostaglandins, which are heavily involved in the intestinal inflammatory response and potently alter lymphatic contractility. We thus evaluated the ability of lymphatics to synthesize and respond to prostaglandins in physiological and inflammatory conditions. Using real time PCR, we analyzed mesenteric lymphatics, arteries, veins, mesothelium and ileum obtained from control animals, TNBS‐treated guinea pigs and their sham counterpart for the following mRNA transcripts: COX‐1, COX‐2, prostacyclin synthase, prostaglandin E (PGE) synthase 1 and 2, prostacyclin receptor, and PGE 2 receptors EP1, EP2, EP3 and EP4. We also measured PGE 2 content in lymphatics by ELISA. When compared to sham and control animals, we observed an upregulation of COX‐2 mRNA and a downregulation of PGE synthase 2 and EP4 receptor mRNAs in lymphatics and ileum of TNBS‐treated animals. Preliminary data also showed an increase in PGE 2 content in lymphatics from TNBS‐treated animals. Our results further suggest alteration of PGE 2 function in lymphatics of TNBS‐treated guinea pigs Supported by the Crohn's and Colitis Foundation of Canada
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".