The Effect of Beetroot on Vascular Contractile Response in Ovariectomized Rats
Bibliographic record
Abstract
Hypertension in women is known to peak dramatically following menopause, potentially attributable to the decreasing levels of sex hormones such as estrogen. Estrogen has regulating effects on nitric oxide (NO) bioavailability, a molecule which plays an important role in regulating blood pressure by dilating arteries. However, in post‐menopausal women estrogen therapy causes many adverse events, and an alternate treatment option is required. Beetroot (BR) is a plant that contains dietary nitrates that can increase blood NO levels. In this study, we tested the hypothesis that ingestion of BR will alter vascular tone and control blood pressure in an ovariectomized rodent model. Twelve‐week old female ovariectomized (OVX) Sprague‐Dawley rats were divided to receive BR juice (containing 18.75 mg nitrates), nitroglycerin (NG) (0.2 mg/kg), estradiol replacement (1.5 mg) or no treatment for 12 weeks (n=4 per group). Isolated aortic rings were mounted in tissue baths and isometric contractile force was measured. Cumulative concentration‐response curves to phenylephrine (PE) (10 −8 M to 10 −5 M) and potassium chloride (KCL 120 mM) were generated to examine contractile function. Superoxide was measured by using chemiluminescence. The aorta rings in the no treatment group developed highest contraction force in response to PE compared to aortic rings from the NG or estradiol‐treated groups (P<0.01). The BR‐treated group had a significantly reduced contractile force compared to no treatment, which was closer to NG and estradiol group levels (P<0.05). BR treatment did not reduce vascular contractions in response to KCL (P>0.05) but significantly reduced superoxide production (P<0.05). These experiments suggest that dietary beetroot would be able to reduce oxidative stress and vascular contraction in response to PE, possibly through the production of nitric oxide. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.003 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".