Ammonia and cortisol are transcriptional regulators of the ammonia transporter Rhcg2 in trout gill pavement cells
Bibliographic record
Abstract
Ammonia is the primary nitrogenous waste excreted across the gills of fish, but the mechanisms involved have never been clearly defined. Several very recent studies have now revealed that Rh glycoproteins have a role as ammonia transporters in fish gills. Based on gene expression studies, Rhcg2 appears to have a main role in this process in the pavement cells of the freshwater trout gill. Little is known however, about how these Rh genes are regulated. Using cultured trout pavement cells we have examined some of the possible transcriptional regulatory mechanisms of Rhcg2. We show that ammonia alone increases the level of Rhcg2 transcripts in the pavement cells while cortisol and 11‐deoxycorticosterone have a potentiating effect on this transcriptional response. We focus on cAMP and mitogen‐activated protein kinase pathways as potential signaling pathways involved in the regulation of Rhcg2 (NSERC Discovery).
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".