nestin: immunohistochemical expression in vessels during the development and progression of pituitary infarction
Bibliographic record
Abstract
The aim of our work was to investigate immunohistochemical expression of nestin, a member of the intermediate filament family, in the adenohypophysial vasculature during the development and progression of pituitary infarction. Non‐tumorous adenohypopheses (45 cases) and pituitary adenomas (34 cases) of various types, all exhibiting acute or healing infarcts were examined. The streptavidin‐biotin‐peroxidase complex method was applied. In areas of adenohypophyses and pituitary adenomas with no infarction, nestin was expressed in scattered capillaries and endothelial cells. In acute infarcts, no nestin was demonstrable in the necrotic capillaries (50 cases). Where newly formed capillaries spread into necrotic zones, nestin expression was noted in all capillaries (25 cases). In the hypocellular, fibrotic scar phase, only few vessels were apparent and immunoreactivity was focal and mild (4 cases). In conclusion, nestin is strongly expressed in newly formed capillaries and is downregulated when infarcts transform to fibrous tissue. Nestin expression may provide valuable insight into the process of pituitary angiogenesis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".