Maternal depressed mood during pregnancy, <i>MTHFR</i> C677T genotype, and vitamin B12 status
Bibliographic record
Abstract
Depression occurs in ~15% of pregnant women, and 1/3 are taking selective serotonin reuptake inhibitors (SSRIs) as antidepressants. Disturbances in methyl metabolism have been found in adults with depression. A variant (C677T) in the gene for methylenetetrahydrofolate reductase ( MTHFR ), an enzyme in methyl metabolism, is also associated with depression. However, the role of methyl metabolism and the MTHFR C677T variant in depression during pregnancy is unknown. We investigated if disturbances in methyl metabolism are associated with maternal depressed mood during pregnancy. Pregnant women (n=176) with the MTHFR 677TT genotype had greater depressed mood (Edinburgh Postnatal Depression Scale, EPDS; and Symptom Questionnaires, SQ) in the 2nd trimester and 5–6 days postpartum (P<0.05) than women with the MTHFR 677CC genotype. In a subset of women, serum vitamin B12 levels at delivery correlated with infant vitamin B12 levels at birth (P<0.01). Serum vitamin B12 levels were lower in infants and their mothers at birth who had depression compared to infants and their mothers without depression or those with depression and treated with SSRIs (P<0.01). These findings suggest that the MTHFR 677TT genotype and low serum vitamin B12 levels are associated with depressed mood during pregnancy and may contribute to the pathology of depression during pregnancy. Grant Funding Source : Interdisciplinary Women's Reproductive Health Research Training Program, and Canadian Institutes of Health Research.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".