Unbalanced Fatty Acid Nutrition High in n‐3 Fatty Acids During Early Development Programs Intestinal Permeability and Later Susceptibility to Experimentally‐Induced Colitis in Rats
Bibliographic record
Abstract
Intrauterine and early postnatal life are periods of physiological plasticity, when adverse environmental events may have long‐lasting effects. The n‐6 and n‐3 fatty acids are important membrane components, precursors for eicosanoids, and ligands for transcription factors. We investigated whether the n‐6 and n‐3 fatty acid supply in gestation and milk‐feeding had enduring effects on colonic barrier integrity and mucosal responsiveness to a chemical insult in rats. Rats were fed diets identical in all nutrients except fatty acids, with 20 % energy from safflower oil to provide high linoleic acid (LA, 18:2n‐6), canola oil with balanced LA and á‐linolenic acid (ALA, 18:3n‐3), or safflower plus fish oil to provide eicosapentaenoic acid (EPA, 20:5n‐3) and docosahexaenoic acid (DHA, 22:6n‐3) throughout gestation and lactation. Male offspring were weaned to chow, and colitis was induced with dinitrobenzene sulfonic acid at 3‐mth age. At 15 days age, colonic crypt depth was highest in the safflower, but paracellular permeability was highest in the fish oil group. Reduced colonic crypt depth and impaired paracellular permeability persisted in fish oil group at 3 mth, with more severe inflammatory response. We show a maternal diet high in n‐3, but low in n‐6 fatty acids has lasting deleterious effects on colonic barrier integrity, predisposing to an exaggerated inflammatory response in later life. Funded by NSERC.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".