WISE‐2005: Lower Body Negative Pressure Treadmill and Resistive Exercise Countermeasures Maintain Physiologic Function in Women during 60‐days of Simulated Microgravity
Bibliographic record
Abstract
INTRODUCTION: We hypothesized that supine LBNP treadmill exercise combined with Flywheel resistive exercise maintains upright physiologic responses following 60‐days of head‐down tilt (HDT) bed rest (BR). METHODS: 16 healthy women (age 25–40 years) underwent 60‐days HDT (‐6°) BR. Women were assigned to either a non‐exercise control group (CON, n=8) or to an exercise group (EX, n=8). EX subjects performed a 40‐min, variable intensity LBNP exercise protocol at foot‐ward forces between 1.0–1.1 times body weight, followed by 10‐min of resting LBNP 3–4 days/week. Resistive exercise of maximal concentric and eccentric supine leg press and heel raise exercises were performed using a flywheel ergometer 2–3 days/week. IRBs approved this study with informed/written consent. RESULTS: Post‐BR VO 2 pk was not different in EX (−3.3±1.2%) but decreased significantly in CON (−21.2±2.1%), p< 0.05. Post‐BR orthostatic tolerance time (mean±se) decreased significantly less in EX (19.3±1.3 to 14.4±1.5 min) than in CON (17.5±0.1 to 9.1±1.5 min), p=0.03. Post‐BR muscle strength decreased significantly in CON, but was preserved in EX. Post‐BR bone resorption was greater than pre‐BR in both groups (p<0.05). Bone formation markers, were significantly elevated (p<0.05) in EX than in CON. CONCLUSIONS: Supine LBNP treadmill exercise along with flywheel resistive exercise maintains upright exercise capacity, orthostatic responses and muscle strength during 60‐days HDT BR. Supported by ESA, CSA, CNES; and NASA: NNJ04HF71G and NNJ04HF72G.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".