The restoration of cerebrovascular myogenic function after hemorrhagic stroke development in stroke prone hypertensive rats
Bibliographic record
Abstract
Hemorrhagic stroke (HS) development in Kyoto Wistar stroke prone hypertensive rats (SHRsp) is associated with the loss of pressure dependent constriction (PDC) in middle cerebral arteries (MCAs). We attempted to restore PDC by administering oral Captopril (CAP, 50 mg/kg/day) or Losartan (LOS, 35 mg/kg/day) treatment after stroke. MCAs were studied using a pressure myograph. MCAs from SHRsp with HS did not elicit constriction to a 100 mmHg pressure step or in response to PKC activation (phorbol dibutyrate 1μM, with 3μM nifedipine). Elevations in [K + ] o (80mM) produced depolarization with attenuated constriction. The MCAs from post stroke SHRsp also could not utilize the sarcoplasmic release of Ca 2+ to produce constraction (vasopressin 0.12 μM, with 3μM nifedipine). Post stroke CAP or LOS treatment restored these functions to pre‐stroke levels within 7 days without altering blood pressure. These functions deteriorated after 30 days of CAP treatment but were maintained past 100 days of LOS treatment. We believe that the loss of PDC after HS is produced by a dysfunctional PKC system and the presence of voltage gated Ca 2+ channel that exhibits an attenuated response to depolarization. The enhanced ability of LOS to restore these functions after HS may be related to the physiological benefits of maintaining high plasma angiotensin II in combination with AT‐1 receptor blockade.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".