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Record W3184086826 · doi:10.1002/smll.202100692

Micro and Nanoscale Technologies for Diagnosis of Viral Infections

2021· review· en· W3184086826 on OpenAlexaff
Fatemeh Nasrollahi, Reihaneh Haghniaz, Vahid Hosseini, Elham Davoodi, Mahboobeh Mahmoodi, Solmaz Karamikamkar, Mohammad Ali Darabi, Yangzhi Zhu, Junmin Lee, Sibel Emi̇r Di̇ltemi̇z, Hossein Montazerian, Sivakoti Sangabathuni, Maryam Tavafoghi, Vadim Jucaud, Wujin Sun, Han‐Jun Kim, Samad Ahadian, Ali Khademhosseini

Bibliographic record

VenueSmall · 2021
Typereview
Languageen
FieldEngineering
TopicBiosensors and Analytical Detection
Canadian institutionsUniversity of Waterloo
FundersSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungSchlumberger Foundation
KeywordsCoronavirus disease 2019 (COVID-19)PandemicNanotechnologyOutbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)DiseaseVirologyRisk analysis (engineering)Infectious disease (medical specialty)MedicineMaterials sciencePathology

Abstract

fetched live from OpenAlex

Viral infection is one of the leading causes of mortality worldwide. The growth of globalization significantly increases the risk of virus spreading, making it a global threat to future public health. In particular, the ongoing coronavirus disease 2019 (COVID-19) pandemic outbreak emphasizes the importance of devices and methods for rapid, sensitive, and cost-effective diagnosis of viral infections in the early stages by which their quick and global spread can be controlled. Micro and nanoscale technologies have attracted tremendous attention in recent years for a variety of medical and biological applications, especially in developing diagnostic platforms for rapid and accurate detection of viral diseases. This review addresses advances of microneedles, microchip-based integrated platforms, and nano- and microparticles for sampling, sample processing, enrichment, amplification, and detection of viral particles and antigens related to the diagnosis of viral diseases. Additionally, methods for the fabrication of microchip-based devices and commercially used devices are described. Finally, challenges and prospects on the development of micro and nanotechnologies for the early diagnosis of viral diseases are highlighted.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.996
Threshold uncertainty score0.417

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.027
GPT teacher head0.260
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations28
Published2021
Admission routes1
Has abstractyes

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