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Record W3185845130 · doi:10.1016/j.molcel.2021.06.009

Transcription-mediated supercoiling regulates genome folding and loop formation

2021· article· en· W3185845130 on OpenAlexfundno aff
Maria Victoria Neguembor, Laura Martin, Álvaro Castells-García, Pablo Aurelio Gómez-García, Chiara Vicario, Davide Carnevali, Jumana AlHaj Abed, Alba Granados, Rubén Sebastián-Pérez, Francesco Sottile, Jérôme Solon, Chao-ting Wu, Melike Lakadamyali, Maria Pia Cosma

Bibliographic record

VenueMolecular Cell · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenomics and Chromatin Dynamics
Canadian institutionsnot available
FundersEuropean Social FundEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentDivision of Civil, Mechanical and Manufacturing InnovationH2020 Marie Skłodowska-Curie ActionsGuangzhou Regenerative Medicine and Health Guangdong LaboratoryAgencia Estatal de InvestigaciónHorizon 2020Faculty of Science and Engineering, University of ManchesterUniversity of California, San FranciscoNational Institutes of HealthResearch Executive AgencyNational Natural Science Foundation of ChinaUniversity of OxfordCentres de Recerca de CatalunyaNational Institute of General Medical SciencesEuropean CommissionMinisterio de Ciencia e InnovaciónGeneralitat de CatalunyaUniversity of EdinburghEuropean Regional Development FundBroad InstituteEuropean Molecular Biology LaboratoryUniversity of PennsylvaniaUniversity of MichiganAlbert Ellis InstituteInstitute of GeneticsAgència de Gestió d'Ajuts Universitaris i de RecercaNational Science Foundation
KeywordsChromatinCohesinBiologyDNA supercoilCell biologyTranscription (linguistics)BiophysicsDNAGeneticsDNA replication

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.571

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.004
GPT teacher head0.182
Teacher spread0.178 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations114
Published2021
Admission routes1
Has abstractno

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