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Record W3186666531

アトピー性皮膚炎におけるIL-33と2 型自然リンパ球

2021· article· ja· W3186666531 on OpenAlexvenueno aff
今井 康友

Bibliographic record

VenuePharma Medica · 2021
Typearticle
Languageja
FieldImmunology and Microbiology
TopicIL-33, ST2, and ILC Pathways
Canadian institutionsnot available
Fundersnot available
KeywordsComputer science
DOInot available

Abstract

fetched live from OpenAlex

免疫反応には自然免疫と獲得免疫がある。この違いは抗原が必要かどうかであって,獲得免疫ではダニやスギといった抗原が必要であり,この抗原特異的な免疫反応が引き起こされる1)。獲得免疫に関与する細胞の例としては,T helper 1 cell(Th1細胞)やTh2細胞がある。これに対して,自然免疫とは,抗原が必要ない,非特異的な免疫反応である。自然免疫の代表的な白血球の例は,2型自然リンパ球(group 2innate lymphoid cells:ILC2)2)である。ILC2は,獲得免疫でいうところのTh2細胞に類似したサイトカインを産生し,アトピー性皮膚炎(atopic dermatitis:AD)の病態に関与する2010年に発見された細胞である。ILC2の活性化に抗原は不要で,抗原の代わりにインターロイキン(interleukin:IL)-4 3)4)やIL-33 5)などのサイトカインの刺激で増殖・活性化する。ILC2はADの病態に深く関与しており,たとえばアトピー性皮膚炎診療ガイドライン2018 6)にもその病態が記載されるに至っている。本稿では,IL-4やIL-33で活性化されるILC2がADにどのように関与しているか概説する。

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesInsufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.620
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.001
Science and technology studies0.0010.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0300.015

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.276
Teacher spread0.251 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; both teacher heads agree on what is shown here.

Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

Explore more

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