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Record W3191864380 · doi:10.1007/s12603-021-1665-8

International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines

2021· article· en· W3191864380 on OpenAlexaff
Míkel Izquierdo, Reshma Aziz Merchant, John E. Morley, Stefan D. Anker, Iván Aprahamian, Hidenori Arai, Mylène Aubertin‐Leheudre, Roberto Bernabei, Eduardo Lusa Cadore, Matteo Cesari, Liang‐Kung Chen, Philipe de Souto Barreto, Gustavo Duque, Luigi Ferrucci, Roger A. Fielding, Antônio García‐Hermoso, Luis Miguel Gutiérrez‐Robledo, Stephen D. R. Harridge, Ben Kirk, Stephen B. Kritchevsky, Francesco Landi, Norman R. Lazarus, Finbarr C. Martin, Emanuele Marzetti, M. Pahor, Robinson Ramírez‐Vélez, Leocadio Rodríguez‐Mañas, Yves Rolland, Jorge G. Ruiz, Olga Theou, Dennis T. Villareal, Debra L. Waters, Chang Won Won, Jean Woo, Bruno Vellas, Maria Fiatarone Singh

Bibliographic record

VenueThe journal of nutrition health & aging · 2021
Typearticle
Languageen
FieldMedicine
TopicNutrition and Health in Aging
Canadian institutionsDalhousie UniversityInstitut Universitaire de Gériatrie de MontréalUniversité du Québec à Montréal
FundersInstituto de Salud Carlos IIINational Institute on AgingNational Institutes of HealthCentro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable
KeywordsCardiorespiratory fitnessMedicineDiseasePhysical therapyExercise prescriptionQuality of life (healthcare)Sedentary lifestyleSarcopeniaIntervention (counseling)Physical medicine and rehabilitationGerontologyStroke (engine)Physical activityInternal medicinePsychiatry

Abstract

fetched live from OpenAlex

The human ageing process is universal, ubiquitous and inevitable. Every physiological function is being continuously diminished. There is a range between two distinct phenotypes of ageing, shaped by patterns of living - experiences and behaviours, and in particular by the presence or absence of physical activity (PA) and structured exercise (i.e., a sedentary lifestyle). Ageing and a sedentary lifestyle are associated with declines in muscle function and cardiorespiratory fitness, resulting in an impaired capacity to perform daily activities and maintain independent functioning. However, in the presence of adequate exercise/PA these changes in muscular and aerobic capacity with age are substantially attenuated. Additionally, both structured exercise and overall PA play important roles as preventive strategies for many chronic diseases, including cardiovascular disease, stroke, diabetes, osteoporosis, and obesity; improvement of mobility, mental health, and quality of life; and reduction in mortality, among other benefits. Notably, exercise intervention programmes improve the hallmarks of frailty (low body mass, strength, mobility, PA level, energy) and cognition, thus optimising functional capacity during ageing. In these pathological conditions exercise is used as a therapeutic agent and follows the precepts of identifying the cause of a disease and then using an agent in an evidence-based dose to eliminate or moderate the disease. Prescription of PA/structured exercise should therefore be based on the intended outcome (e.g., primary prevention, improvement in fitness or functional status or disease treatment), and individualised, adjusted and controlled like any other medical treatment. In addition, in line with other therapeutic agents, exercise shows a dose-response effect and can be individualised using different modalities, volumes and/or intensities as appropriate to the health state or medical condition. Importantly, exercise therapy is often directed at several physiological systems simultaneously, rather than targeted to a single outcome as is generally the case with pharmacological approaches to disease management. There are diseases for which exercise is an alternative to pharmacological treatment (such as depression), thus contributing to the goal of deprescribing of potentially inappropriate medications (PIMS). There are other conditions where no effective drug therapy is currently available (such as sarcopenia or dementia), where it may serve a primary role in prevention and treatment. Therefore, this consensus statement provides an evidence-based rationale for using exercise and PA for health promotion and disease prevention and treatment in older adults. Exercise prescription is discussed in terms of the specific modalities and doses that have been studied in randomised controlled trials for their effectiveness in attenuating physiological changes of ageing, disease prevention, and/or improvement of older adults with chronic disease and disability. Recommendations are proposed to bridge gaps in the current literature and to optimise the use of exercise/PA both as a preventative medicine and as a therapeutic agent.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.011
metaresearch head score (Gemma)0.028
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.023
Threshold uncertainty score0.061

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0110.028
Meta-epidemiology (narrow)0.0030.001
Meta-epidemiology (broad)0.0040.009
Bibliometrics0.0080.004
Science and technology studies0.0010.001
Scholarly communication0.0030.002
Open science0.0080.004
Research integrity0.0080.006
Insufficient payload (model declined to judge)0.0160.012

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.096
GPT teacher head0.436
Teacher spread0.341 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations1,166
Published2021
Admission routes1
Has abstractyes

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