Test of the Serotonin Transporter Gene × Early Life Stress Interaction Effect on Subjective Well‐Being and Loneliness Among Japanese Young Adults
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Bibliographic record
Abstract
Abstract This study investigated whether aspects of early life environment (quality of parental relationship, frequency of parental violence including disciplinary violence, amount of parental attention, and family income during childhood) would affect one's subjective well‐being and loneliness later in life (i.e., during young adulthood). This study also investigated whether the negative influence of early life stress is greater among individuals with the SS genotype of the serotonin transporter‐linked polymorphic region (5‐HTTLPR) in the serotonin transporter gene. Participants were 568 university students whose genotypes were identified using nail samples. They reported their current levels of subjective well‐being and loneliness as well as their recollections of their early family environments. The results showed that less stressful early life environments, such as high levels of parents' relationship quality and parental attention, were positively (negatively) associated with subjective well‐being (loneliness), while frequent parental violence was negatively (positively) associated with subjective well‐being (loneliness). Nevertheless, the gene × environment interaction effects were consistently non‐significant—the SS genotype did not accentuate the effects of early life stress.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it