Does Age Matter in Psoriatic Arthritis? A Narrative Review
Bibliographic record
Abstract
Psoriatic arthritis (PsA) affects approximately 0.8% of the general population. PsA, together with psoriasis (PsO), constitute psoriatic disease (PsD). Comorbidities play an important role in the clinical expression and treatment of PsD. Aging adds another level of complexity, partly because age directly accrues increasing risk of comorbidities, but also because of its complex interactions with several factors such as depression and social determinants. Aging seems to have a "paradoxical association" with cardiovascular comorbidities, for which the relative risk is more pronounced in younger patients with PsD. It also affects treatment decisions and treatment response in patients with PsD. Finally, there is convincing evidence that there are clinical, genetic, and histopathological differences between early- and late-onset PsA and PsO. Herein, we review the effect of age in patients with PsD, with a focus on PsA, highlighting the need to consider this factor in routine clinical practice as well as in research.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.003 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".