Contact-dependent cleavage of Jagged1 in oocytes reveals potential bidirectional Notch signaling during follicular growth in the mouse
Bibliographic record
Abstract
Dear Editor, Growth and development of the ovarian follicle depends on coordinated signaling between the germ-line and somatic cells. Among the interactions so far identified is that coupling Jagged ligand, expressed in the germ cell, to the Notch receptor, expressed in granulosa cells [1]. Targeted deletion of Jag1 or Notch2 in the oocyte or granulosa cells, respectively, leads to abnormalities in primordial follicle formation [2, 3]. Defects including reduced granulosa cell proliferation and increased atresia also occur during follicular growth and are associated with subfertility [2, 4], suggesting that Jagged–Notch signaling may play a role throughout folliculogenesis. Both Jagged and Notch are anchored in the plasma membrane (reviewed in [5]). In the canonical pathway, the binding of Jagged triggers successive cleavages of Notch by a disintegrin and metalloproteinase (ADAM) and γ-secretase proteases. These release the Notch intracellular domain (NICD) that...
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".